Endothelial Metabolic Control of Lymphangiogenesis

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Pengchun YuMichael Simons

Abstract

Lymphangiogenesis is an important developmental process that is critical to regulation of fluid homeostasis, immune surveillance and response as well as pathogenesis of a number of diseases, among them cancer, inflammation, and heart failure. Specification, formation, and maturation of lymphatic blood vessels involves an interplay between a series of events orchestrated by various transcription factors that determine expression of key genes involved in lymphangiogenesis. These are traditionally thought to be under control of several key growth factors including vascular growth factor-C (VEGF-C) and fibroblast growth factors (FGFs). Recent insights into VEGF and FGF signaling point to their role in control of endothelial metabolic processes such as glycolysis and fatty acid oxidation that, in turn, play a major role in regulation of lymphangiogenesis. These advances have significantly increased our understanding of lymphatic biology and opened new therapeutic vistas. Here we review our current understanding of metabolic controls in the lymphatic vasculature.

References

Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KaipainenK Alitalo
May 30, 1997·Science·M JeltschK Alitalo
Jun 17, 2000·American Journal of Human Genetics·A IrrthumM Vikkula
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hajime KuboKari Alitalo
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Young-Kwon HongGuillermo Oliver
May 21, 2003·The Journal of Experimental Biology·John E Wilson
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lynn K ChangArja Kaipainen
Sep 20, 2005·Nature Genetics·Natasha L HarveyGuillermo Oliver
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
May 25, 2007·Nature Reviews. Molecular Cell Biology·Ralf H Adams, Kari Alitalo
Oct 3, 2007·Genes & Development·R Sathish SrinivasanGuillermo Oliver
Nov 28, 2007·Annual Review of Pathology·Terhi Karpanen, Kari Alitalo
Dec 7, 2007·Cardiovascular Research·Masahiro MurakamiMichael Simons
Sep 9, 2008·The Journal of Clinical Investigation·Masahiro MurakamiMichael Simons
Oct 22, 2008·Nature·Mathias FrançoisPeter Koopman
Dec 6, 2008·Genes & Development·Nicole C JohnsonGuillermo Oliver
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Aug 15, 2009·The American Journal of Pathology·Hwee Ying LimVéronique Angeli
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Feb 25, 2010·Cell·Tuomas Tammela, Kari Alitalo
Jun 15, 2011·Physiology·Mathias FrancoisBenjamin M Hogan
Nov 9, 2011·Nature Medicine·Kari Alitalo
Sep 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Renhai CaoYihai Cao
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eric C CheungKaren H Vousden
Feb 9, 2013·The Journal of Clinical Investigation·Yong DengMichael Simons
Aug 6, 2013·Cell·Katrien De BockPeter Carmeliet
Mar 5, 2014·The Journal of Clinical Investigation·Wei ZhengKari Alitalo
Mar 5, 2014·The Journal of Clinical Investigation·Ying Yang, Guillermo Oliver
Aug 19, 2014·Microvascular Research·Pengchun YuMichael Simons
Aug 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sunday S OladipupoDavid M Ornitz
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Georgia ZarkadaKari Alitalo
Mar 17, 2015·Nature Cell Biology·Lindsey K Boroughs, Ralph J DeBerardinis
Apr 2, 2015·Nature·Robert A Egnatchik, Ralph J DeBerardinis
Apr 2, 2015·Nature·Sandra SchoorsPeter Carmeliet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

© 2022 Meta ULC. All rights reserved