Endothelial modulation of the coronary vasculature in vessels perfused via mature collaterals

Circulation
F W SellkeD G Harrison

Abstract

Previous in vivo studies have shown that vasopressin, which releases the endothelium-derived relaxing factor and constricts coronary smooth muscle, produces augmented constriction of coronary microvessels perfused by mature collaterals. We hypothesized that chronic perfusion through collaterals produces endothelial dysfunction in the recipient vasculature. Mature collaterals were stimulated in mongrel dogs by the ameroid constrictor technique. After 3-6 months, rings of conduit vessels (obtuse marginals) were studied in organ chambers, and coronary microvessels (100-220 microns) were studied in a pressurized, no-flow state with a microvessel imaging apparatus. Eleven dogs were used as controls. Large vessels were preconstricted with prostaglandin F2 alpha to 30-70% of the maximum potassium chloride tension, and microvessels were preconstricted to 20-60% of the baseline diameter with the thromboxane mimetic U46619. Relaxations to the receptor-mediated agents acetylcholine and ADP were markedly impaired in collateral-dependent coronary microvessels, whereas relaxations to nitroglycerin were enhanced compared with microvessels from control dogs. Relaxation to the calcium ionophore A23187, which releases the endothelium-derived rel...Continue Reading

References

Sep 1, 1985·Journal of Cardiovascular Pharmacology·G A Kopia, R E Valocik
Nov 1, 1987·The Journal of Clinical Investigation·V M MillerP M Vanhoutte
Jul 1, 1985·Cardiovascular Research·G A PantelyJ D Bristow
Nov 1, 1983·Circulation Research·R F Furchgott

❮ Previous
Next ❯

Citations

Feb 1, 1993·Catheterization and Cardiovascular Diagnosis·K YamanishiA Igawa
May 1, 1991·Journal of the American College of Cardiology·D G Harrison
Jul 1, 1991·Trends in Cardiovascular Medicine·T F LüscherF C Tanner
Oct 12, 2000·Nihon rinsho. Japanese journal of clinical medicine·Y SaitoR Nagai
Jan 13, 1998·Journal of the American College of Cardiology·J H TraverseR J Bache
Feb 15, 2001·Progress in Retinal and Eye Research·I O HaefligerT F Lüscher
Jun 26, 1998·Journal of Cardiovascular Pharmacology·B B QuebbemannR J Bache
Oct 22, 1998·Journal of Cardiovascular Pharmacology·Y IshibashiR J Bache
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Nicolai GruhnJan Aldershvile
Dec 23, 2004·Journal of Cardiovascular Pharmacology·Keiko TakahashiSatsuki Koida
Mar 1, 1996·Clinical and Experimental Pharmacology & Physiology·D G HarrisonR C Venema
Feb 24, 2004·Journal of Applied Physiology·Cristine L HeapsDouglas K Bowles
Aug 1, 1994·The Journal of Clinical Investigation·K HaradaM Simons
Jul 5, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Benjamin N MorrisRoger L Royster
Mar 3, 2010·The Journal of Physiology·Patrick N ColleranRonald L Terjung
Apr 30, 2009·The International Journal of Biochemistry & Cell Biology·Hugo R AriasShaker A Mousa
Feb 1, 1995·Medical Hypotheses·R P DanisJ Savage
Mar 21, 2006·Vascular Pharmacology·Nilesh M PandyaDev D Santani
May 17, 2005·Journal of the American College of Cardiology·Ahmed TawakolHenry Gewirtz
Jan 5, 2016·Journal of Heart and Cardiology·A A Arce-EsquivelR L Terjung
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C L HeapsJ L Parker
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C L HeapsJ L Parker
Jun 2, 2006·American Journal of Physiology. Cell Physiology·Charles D Searles
Jan 1, 1996·Vascular Medicine·J M Isner
Nov 24, 1999·Journal of Applied Physiology·K L GriffinJ L Parker
Nov 15, 1997·The American Journal of Physiology·J A RappsJ L Parker
Jan 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Yufeng ZhangMichael Simons
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Cristine L HeapsJanet L Parker
May 8, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Daphne MerkusCristine L Heaps
Jul 7, 2000·Pharmacology & Therapeutics·T KomaruK Shirato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.