Oct 11, 2003

Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages

Biochemical and Biophysical Research Communications
Heiko Mühl, Josef Pfeilschifter

Abstract

Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages.

  • References22
  • Citations21

Citations

Mentioned in this Paper

Tumor Necrosis Factor-alpha
Cardiovascular System
Nitric Oxide Synthase Type III
NOS3 protein, human
Monocytes as Percentage of Blood Leukocytes (Lab Test)
Macrophage
Inflammation
Cardiovascular system DRUGS
Physiopathological
Nitric Oxide Synthase

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.