Endothelial nitric oxide synthase: from structure to function in one aspartic substitution

Kidney International
Michael S Goligorsky

Abstract

Cherney and co-workers examine the functional phenotype of the G894T eNOS polymorphism in a selected group of apparently healthy subjects. The investigators used L-arginine infusion and induced changes in renal hemodynamics. While L-arginine increased effective plasma flow and glomerular filtration rate in GG subjects, these responses were blunted in GT/TT subjects, suggesting that either the G894T polymorphism impairs eNOS function, or GG subjects exhibit augmented eNOS responsiveness to L-arginine. The complexity of this seemingly straightforward conclusion deserves elaboration.

References

Jun 15, 1993·Biochemical and Biophysical Research Communications·H TsukaharaM S Goligorsky
Dec 31, 1997·The Journal of Biological Chemistry·J C SalernoS S Gross
Apr 6, 2006·Circulation·Ulrich Förstermann, Thomas Münzel
Jul 15, 2006·Journal of Molecular and Cellular Cardiology·Peter F MountDavid A Power
Apr 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mandar S JoshiJohn Anthony Bauer
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mahesh S JoshiJack R Lancaster
Dec 19, 2007·Pharmacogenomics·Glen E CookePhilip F Binkley
Nov 28, 2008·Kidney International·David Z I CherneyJudith A Miller

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