Endothelial nitric oxide synthase gene expression is associated with hypertension in autosomal dominant polycystic kidney disease

Cardiorenal Medicine
Ismail KocyigitOktay Oymak

Abstract

Early occurrence of hypertension is the prominent feature of autosomal dominant polycystic kidney disease (ADPKD). The role of angiotensin-converting enzyme (ACE) gene polymorphism and endothelial nitric oxide synthase (eNOS) gene polymorphism in the clinical course of ADPKD is not well understood. However, data about the expression of these genes are lacking. Thus, we aimed to investigate the polymorphisms and expressions of both the ACE and eNOS genes that affect hypertension in ADPKD. Whole blood samples were obtained from all participants. ACE and eNOS gene polymorphisms and their expressions were analyzed in 78 ADPKD patients and 30 controls. Gene expressions were assessed by quantitative real-time PCR. Twenty-four-hour blood pressure monitoring was performed for the diagnosis of hypertension in all study participants. eNOS expression and the estimated glomerular filtration rate were found to be significantly higher in ADPKD patients without hypertension than in those with hypertension. Each unit of increase in eNOS expression led to a 0.88-fold decrease (95% CI: 0.80-0.96) in the risk of hypertension in multiple logistic regression analysis. eNOS gene expression is independently predictive of hypertension in the ADPKD pop...Continue Reading

Citations

Jul 1, 2015·Expert Opinion on Investigational Drugs·Domenico SantoroValeria Cernaro
Jan 5, 2016·Acta Pharmacologica Sinica·Juan DuBing Shen
Jan 19, 2018·Cardiorenal Medicine·Adam Whaley-Connell, James R Sowers
May 28, 2016·Chonnam Medical Journal·JongUn LeeSoo Wan Kim
Apr 26, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ismail KocyigitBulent Tokgoz
Apr 11, 2020·KI Reports·Ivana Y Kuo, Arlene B Chapman
Mar 28, 2017·Kidney International·Adam Whaley-Connell, James R Sowers

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