Endothelial nitric oxide synthase gene polymorphism relationship with semen parameters and oxidative stress in infertile oligoasthenoteratozoospermic men

Urology
T MostafaDalia M El-Saied

Abstract

To assess endothelial nitric oxide synthase (eNOS) gene polymorphism relationship with semen parameters and oxidative stress in infertile oligoasthenoteratozoospermic (OAT) men. Three hundred subjects were divided into healthy fertile men (n = 80) and infertile OAT men (n = 220). They were subjected to history taking, clinical examination, and semen analysis in addition to malondialdehyde and glutathione peroxidase estimation in seminal plasma. Polymorphisms of eNOS G894T and T786C genotypes in peripheral blood were identified by the polymerase chain reaction-restriction fragment length polymorphism analysis. Comparing infertile OAT men with fertile controls, eNOS genotype G894T demonstrated prevalence of 36.8% vs 50% for wild type (GG), 35.0% vs 47.5% for heterozygous type (GT), and 28.2% vs 2.5% for mutant homozygous type (TT). Compared with GG homozygotes, carriers with A allele exhibited >1.716-fold increased risk of OAT occurrence. Comparing infertile OAT men with fertile controls, eNOS genotype T786C demonstrated prevalence of 37.3% vs 51.3% for wild type (TT), 32.7% vs 45% for heterozygous type (TC), and 30% vs 3.7% for mutant type (CC) with significant differences. Compared with TT homozygotes, carriers with C allele ex...Continue Reading

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Citations

Mar 12, 2016·Journal of Advanced Research·Taymour Mostafa, Mai Taymour
Dec 1, 2015·BioMed Research International·Bolan Yu, Zhaofeng Huang
Apr 22, 2020·Environmental Science and Pollution Research International·Faezeh Sadat Mousavi-Nasab, Abasalt Hosseinzadeh Colagar
Aug 5, 2019·Cellular and Molecular Life Sciences : CMLS·Erfaneh BaratiMohammad Karimian
Apr 4, 2021·International Journal of Molecular Sciences·Daniele SantiManuela Simoni
Sep 25, 2021·Expert Review of Molecular Diagnostics·Mohammad KarimianMohaddeseh Behjati
Oct 1, 2021·Human Fertility : Journal of the British Fertility Society·Taymour MostafaOmar Ali

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