Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

Cardiovascular Journal of Africa
Hakan TaşolarHasan Pekdemir

Abstract

Endothelial dysfunction plays a key role in the aetiopathogenesis of slow coronary flow (SCF) even if there is no obstructive epicardial lesion. Reduced plasma levels of endothelial nitric oxide synthase (eNOS) are an important indicator of endothelial dysfunction. We aimed to determine plasma levels of eNOS and their relationship with exercise in patients with SCF. Twenty-two patients with SCF in at least one coronary artery and 17 healthy individuals were included in this study. The TIMI frame count method was used to determine SCF. Plasma levels of eNOS before and after effort were determined in the patient and control groups. Basal eNOS levels in the patient group were lower than in the control group (p = 0.040), and plasma eNOS levels after exercise decreased more significantly in the patient group compared to the control group (p = 0.002). Median decreases of eNOS in response to exercise were higher in the SCF group than in the control group (p < 0.001), and the decrease observed in the control group was not statistically significant (p = 0.35). There were significantly negative correlations between TIMI frame count and plasma levels of eNOS at baseline and after exercise (r = -0.51, p = 0.015, r = -0.58, p = 0.005, respe...Continue Reading

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Citations

Aug 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Maria KharitonovaAnatoly Skalny
Apr 1, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jinguo Zhu, Bingren Gao
Oct 31, 2014·Coronary Artery Disease·Ying XuMin Pan
May 29, 2020·BMC Cardiovascular Disorders·Yao-Dong DingHai-Long Ge

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