Endothelial nitric oxide synthase polymorphisms affect the changes in blood pressure and nitric oxide bioavailability induced by propofol

Nitric Oxide : Biology and Chemistry
Gustavo H Oliveira-PaulaJose E Tanus-Santos

Abstract

Propofol anesthesia is usually accompanied by hypotension, which is at least in part related to enhanced endothelial nitric oxide synthase (NOS3)-derived NO bioavailability. We examined here whether NOS3 polymorphisms (rs2070744, 4b/4a VNTR, rs3918226 and rs1799983) and haplotypes affect the changes in blood pressure and NO bioavailability induced by propofol. Venous blood samples were collected from 168 patients at baseline and after 10 min of anesthesia with propofol 2 mg/kg administered intravenously by bolus injection. Genotypes were determined by polymerase chain reaction and haplotype frequencies were estimated. Nitrite concentrations were measured by using an ozone-based chemiluminescence assay, while NOx (nitrites + nitrates) levels were determined by using the Griess reaction. We found that CT + TT genotypes for the rs3918226 polymorphism, the ba + aa genotypes for the 4b/4a VNTR and the CTbT haplotype were associated with lower decreases in blood pressure and lower increases in nitrite levels after propofol anesthesia. On the other hand, the TCbT and CCbT haplotypes were associated with more intense decreases in blood pressure and higher increases in nitrite levels in response to propofol. Our results suggest that NOS...Continue Reading

Citations

Nov 7, 2018·Pharmacogenomics·Marcelo R LuizonJose E Tanus-Santos
Aug 17, 2018·Current Drug Targets·Gustavo H Oliveira-Paula, Jose E Tanus-Santos
Aug 5, 2020·Expert Opinion on Drug Metabolism & Toxicology·Cezar Kayzuka Cotta FilhoRiccardo Lacchini
Jan 8, 2021·European Journal of Clinical Pharmacology·Gustavo H Oliveira-PaulaRiccardo Lacchini
Dec 2, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wen WangHaiyan Lu
Nov 27, 2021·Basic & Clinical Pharmacology & Toxicology·Gustavo H Oliveira-PaulaJose E Tanus-Santos

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