Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice

Journal of Vascular Research
Jose M PimientoAlan Dardik

Abstract

Age-associated changes in endothelial nitric oxide synthase (eNOS) expression have not been definitively linked to the pathophysiology of aortic aneurysms. We examined the role of eNOS in human patients and an age-appropriate mouse model. eNOS transcripts and immunodetectable protein were assessed by quantitative PCR and immunohistochemistry in human ascending thoracic aneurysms (n = 29) and referent aortae (n = 31). Carotid aneurysms were induced with CaCl2 in young adult (3 months) and aged (18 months) C57BL/6 and eNOS-knockout (eNOS-KO) mice. eNOS transcripts and protein were reduced in human aneurysms compared with controls, although aortic eNOS expression also decreased with patient age. Aged wild-type mice had significantly larger aneurysm diameter than young adult mice. Aged wild-type mice had reduced eNOS transcripts and protein compared with young adult mice. Aged eNOS-KO mice had smaller aneurysms compared with aged wild-type mice but similar size aneurysms compared with young eNOS-KO and young wild-type mice. eNOS expression is reduced in both aged human and aged mouse endothelium and eNOS expression is linked to aneurysm expansion in aged but not young adult mice. These findings support the relevance of age-associat...Continue Reading

References

Mar 1, 1988·The Journal of Clinical Investigation·S D GertzD Eisenberg
Nov 1, 1995·Journal of Clinical Epidemiology·R F Gillum
Nov 1, 1995·Experimental Physiology·V B Schini-Kerth, P M Vanhoutte
Sep 15, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J K LeeR W Thompson
Mar 9, 2002·Current Problems in Surgery·Robert W ThompsonJason K Lee
Mar 21, 2002·Annals of Vascular Surgery·Jason M JohanningJames R Elmore
Feb 1, 2003·Trends in Pharmacological Sciences·Giuseppe CirinoWilliam C Sessa
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan Daugherty, Lisa A Cassis
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanfen XiongB Timothy Baxter
Mar 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Seinosuke Kawashima, Mitsuhiro Yokoyama
May 26, 2004·Journal of Cell Science·William C Sessa
Jul 16, 2004·The Journal of Clinical Investigation·John A Curci, Robert W Thompson
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Katherine A BlackwellZvonimir S Katusic
Sep 8, 2004·Journal of Molecular and Cellular Cardiology·Wei LiThomas H Hintze
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mariarosaria BucciGiuseppe Cirino
Jul 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul C Y TangGeorge Tellides
Sep 29, 2005·Microvascular Research·Sung Tae ChaM Rocio Sierra-Honigmann
Jul 11, 2006·American Journal of Physiology. Cell Physiology·Erin LepicQingping Feng
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vineet BhandariJack A Elias
Dec 22, 2006·Annals of the New York Academy of Sciences·John A CowanGilbert R Upchurch
Jan 16, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael L McCormickNeal L Weintraub
Mar 24, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark W Majesky

❮ Previous
Next ❯

Citations

Jul 18, 2012·European Journal of Applied Physiology·Euhan J LeeChristopher P O'Donnell
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·E MadernaC Marras
Apr 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Donald D LundDonald D Heistad
Sep 13, 2011·Current Problems in Surgery·Michael E ZenilmanJonathan C Berger
Jul 21, 2015·Cirugia y cirujanos·Liliana García-OrtizJonathan Sánchez-Hernández
Oct 3, 2021·British Journal of Pharmacology·Marta ToralJuan Miguel Redondo
May 8, 2019·Journal of Vascular Research·Kimihiro IgariDai Yamanouchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.