Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study.

PloS One
Johan LorenzenDanilo Fliser

Abstract

Endothelial progenitor cells (EPCs) mediate vascular repair and regeneration. Their number in peripheral blood is related to cardiovascular events in individuals with normal renal function. We evaluated the association between functionally active EPCs (cell culture) and traditional cardiovascular risk factors in 265 patients with chronic kidney disease stage V receiving hemodialysis therapy. Thereafter, we prospectively assessed cardiovascular events, e.g. myocardial infarction, percutaneous transluminal coronary angioplasty (including stenting), aorto-coronary bypass, stroke and angiographically verified stenosis of peripheral arteries, and cardiovascular death in this cohort. In our patients EPCs were related only to age (r=0.154; p=0.01). During a median follow-up period of 36 months 109 (41%) patients experienced a cardiovascular event. In a multiple Cox regression analysis, we identified EPCs (p=0.03) and patient age (p=0.01) as the only independent variables associated with incident cardiovascular events. Moreover, a total of 70 patients died during follow-up, 45 of those due to cardiovascular causes. Log rank test confirmed statistical significance for EPCs concerning incident cardiovascular events (p=0.02). We found a s...Continue Reading

References

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Citations

Feb 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alejandro R Chade
Jul 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jula K InrigRobert D Toto
Sep 21, 2011·PloS One·Giovana S Di MarcoDetlef Lang
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Jan 13, 2012·American Journal of Nephrology·Cheuk-Chun SzetoPhilip Kam-Tao Li
May 12, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amaryllis H Van CraenenbroeckMarie M Couttenye
May 17, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Amaryllis H Van CraenenbroeckViviane M Conraads
Jun 5, 2020·Toxins·Maribel Diaz-RicartGines Escolar
Aug 21, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Maricica PacurariFadi G Hage
Dec 1, 2013·Regenerative Medicine Research·Hui-Bin LiuZhi-Ren Zhang
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis

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Methods Mentioned

BETA
percutaneous transluminal coronary angiography
flow cytometry
percutaneous transluminal coronary angioplasty
density gradient centrifugation

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
GraphPad Prism

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