Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy

PloS One
Elisa Cuadrado-GodiaJaume Roquer

Abstract

The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. During follow-up, 19 patients (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with a...Continue Reading

References

Apr 24, 2002·Seminars in Cell & Developmental Biology·Shahin RafiiDavid Lyden
May 4, 2002·Stroke; a Journal of Cerebral Circulation·David C HessJo Carothers
Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Nov 4, 2004·Cerebrovascular Diseases·P-J TouboulUNKNOWN Advisory Board of the 3rd Watching the Risk Symposium 2004, 13th European Stroke Conference
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Oct 22, 2005·Annals of Neurology·Hakan AyWalter J Koroshetz
Nov 8, 2005·Thrombosis and Haemostasis·Sunil K NadarAndrew D Blann
Sep 23, 2006·The New England Journal of Medicine·Birgit AssmusAndreas M Zeiher
Oct 19, 2006·Journal of the American College of Cardiology·Christopher J BoosAndrew D Blann
Mar 22, 2007·JAMA : the Journal of the American Medical Association·Ph Gabriel StegUNKNOWN REACH Registry Investigators
May 12, 2007·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
May 16, 2007·Archives of Neurology·Jaume RoquerJosé E Martínez-Rodríguez
Oct 11, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·María GrauJaume Marrugat
Dec 8, 2007·Stroke; a Journal of Cerebral Circulation·Hon-Kan YipHsueh-Wen Chang
Sep 13, 2008·American Journal of Hypertension·Takashi UmemuraYukihito Higashi
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Juan F Arenillas
Aug 20, 2011·Stroke; a Journal of Cerebral Circulation·Jaume RoquerUNKNOWN ARTICO Study
Feb 10, 2012·Respiratory Medicine·Marco Matteo CicconePierluigi Carratù
Mar 1, 2012·Frontiers in Physiology·K WilliamsonM Y Alexander
May 26, 2012·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandUNKNOWN Council on Quality of Care and Outcomes Research
Aug 23, 2012·JAMA : the Journal of the American Medical Association·Hester M Den RuijterMichiel L Bots
Jul 5, 2013·Neurology·Angel OisJaume Roquer

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Citations

Jul 23, 2019·European Journal of Ophthalmology·Dario Pasquale MuccioloAnna Maria Gori
Jan 1, 2020·European Heart Journal·Gian Paolo FadiniArshed Ali Quyyumi
Nov 11, 2020·Stem Cell Reviews and Reports·Marek KukumbergEvelyn K F Yim

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SSS
SPSS
Sonosite MIcroMaxx IMT
TOAST

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