PMID: 3970136Feb 1, 1985Paper

Endothelial regeneration. VII. Lack of intimal proliferation after defined injury to rat aorta

The American Journal of Pathology
M A Reidy, M Silver

Abstract

Rat aortas were denuded of endothelium by the use of catheters, which removed either a zone 10-15 cells wide or a zone 90-120 cells wide. Each animal received 3H-thymidine at 1, 16, and 24 hours before death, and groups of 3 animals were killed at 2, 3, 4, and 7 days after the small injury or 4, 5, 7, 14, and 42 days after the large injury. Scanning electron microscopy showed that the smaller injury was rehealed with endothelium by approximately 72 hours, and the large injury was repopulated by endothelium after 7-8 days. In aortas subjected to the 10-15-cell-wide injury, no intimal thickening nor intimal smooth-muscle proliferation was observed. After the larger injury, no obvious intimal thickening was present, although a few intimal cells were observed at sites where the internal elastic lamella was discontinuous. No significant increase in smooth-muscle-cell replication was detected in these aortas at any time after injury.

Related Concepts

Ascending Aorta Structure
Catheterization
Cell Division Phases
Endothelium
Scanning Electron Microscopy
Muscle, Smooth, Vascular

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.