Endothelial Repair and Regeneration Following Intimal Injury

Journal of Cardiovascular Translational Research
Belay Tesfamariam

Abstract

Coronary artery intervention using device implants significantly reduce the risk of restenosis and the need for revascularization but are associated with endothelial denudation and impaired function. This may be due to incomplete endothelial recovery as a result of intimal injury, presence of polymer and/or high antiproliferative drug accumulation in the intima. The permanent presence of a metal prosthesis or polymer may impair the proliferation of resident endothelial cells to cover empty areas. Attention has focused on the robust replenishment of endothelial monolayer by recruitment of circulating endothelial progenitor cells derived from the bone marrow to areas of endothelial injury. The balance between endothelial damage and repair is critical for the maintenance of intimal integrity, function, and prevention of thrombotic complications. This review will discuss on the aftereffects of intravascular device implants on endothelial injury and the pathways involved in endothelial repair and regeneration with an emphasis on endothelial progenitor cells.

References

Jun 2, 1998·Kidney International·B J Ballermann
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J AraA Darnell
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Jun 25, 2003·Circulation·Paul E SzmitkoSubodh Verma
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·S P JacksonS Kulkarni
Oct 22, 2003·Circulation·Paul E SzmitkoSubodh Verma
Jun 17, 2004·Seminars in Vascular Medicine·Steffen MassbergMeinrad Gawaz
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Nov 6, 2004·Science·Takahiro Shintani, Daniel J Klionsky
Nov 18, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas G NührenbergDietlind Zohlnhöfer
Nov 30, 2004·The American Journal of Cardiology·Arnon BlumHarold L Dauerman
Feb 16, 2005·Thrombosis and Haemostasis·Andrew D BlannFrançoise Dignat-George
Jul 19, 2005·Journal of the American College of Cardiology·Mario TogniOtto M Hess
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten VowinkelD Neil Granger
Oct 27, 2005·European Heart Journal·Sjoerd H HofmaPatrick W Serruys
Dec 13, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·James A S MuldowneyDouglas E Vaughan
Jan 20, 2007·International Journal of Cardiology·Mario TogniOtto M Hess
Feb 20, 2007·Journal of the American College of Cardiology·Eduard ShantsilaGregory Y H Lip
Feb 6, 2008·Cardiovascular Research·Amelia BarilliOvidio Bussolati
Feb 22, 2008·Journal of Cardiovascular Pharmacology·Belay Tesfamariam
May 20, 2008·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Belay Tesfamariam
Jul 19, 2008·American Journal of Hypertension·En-Hui YaoKoichi Matsumoto
Jul 23, 2008·Hypertension·Tomonori SugiuraToyoaki Murohara
Jul 26, 2008·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Jan 24, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philipp KümpersMarion Haubitz
Apr 22, 2009·Journal of Cellular and Molecular Medicine·F SabatierF Dignat-George
May 28, 2009·Annals of Biomedical Engineering·Juan M Jiménez, Peter F Davies
Oct 10, 2009·The American Journal of Pathology·Shin-ichiro HayashiShigeru Nakashima
Aug 3, 2010·Journal of Molecular and Cellular Cardiology·Matthew R Richardson, Mervin C Yoder
Jan 6, 2011·Circulation. Cardiovascular Interventions·Gaku NakazawaRenu Virmani

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Citations

Jan 4, 2017·Journal of Diabetes·Yi Shi, Paul M Vanhoutte
Oct 5, 2017·Journal of Biomedical Materials Research. Part a·Sachiro KakinokiTetsuji Yamaoka
Aug 2, 2017·International Journal of Molecular Sciences·Ding-Yuan TianYun Wang
Feb 25, 2020·BioMed Research International·Hexi ZhangHui Gong
Oct 20, 2018·Obesity Science & Practice·S T RashidS B Wheatcroft
Jan 5, 2019·Journal of Cell Science·Jiahui Cao, Hans Schnittler
Sep 25, 2018·Chinese Medical Journal·Ling-Bing MengTao Gong
May 5, 2017·Cardiovascular and Interventional Radiology·Marja Ter MeerLambertus P van den Heuvel
Mar 7, 2019·Journal of the Chinese Medical Association : JCMA·Bin HeHui-Min Chu
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Xiaoli WangXiaoheng Liu
Oct 5, 2021·Frontiers in Cell and Developmental Biology·Ji-Ting LiuYing-Xin Qi

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