Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?

Respiratory Research
Sukhwinder Singh Sohal

Abstract

Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of airway epithelial cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Reimann and colleagues, showed increased expression of S100A4 in vasculature of human COPD and murine lungs. It is quite possible that the process of endothelial to mesenchymal transition (EndMT) is active in COPD lungs which we wish to comment on.

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Citations

Feb 10, 2017·Nature Communications·Elisabetta DejanaMichael Simons
Jun 25, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mohit Kumar JollySukhwinder Singh Sohal
May 22, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mathew Suji EapenSukhwinder Singh Sohal
Nov 20, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mathew Suji EapenSukhwinder Singh Sohal
Mar 14, 2019·Physiological Reviews·Sonsoles Piera-Velazquez, Sergio A Jimenez
Sep 25, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Toshio SuzukiJames West
Apr 4, 2021·Multiple Sclerosis and Related Disorders·Fan GeWenhua Liang
Oct 21, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Surajit DeySukhwinder Singh Sohal

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Methods Mentioned

BETA
biopsies

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