Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis

Stem Cells International
Hsiao-Fan Chen, Kou-Juey Wu

Abstract

Tumor hypoxia is associated with malignant biological phenotype including enhanced angiogenesis and metastasis. Hypoxia increases the expression of vascular endothelial cell growth factor (VEGF), which directly participates in angiogenesis by recruiting endothelial cells into hypoxic area and stimulating their proliferation, for increasing vascular density. Recent research in tumor biology has focused on the model in which tumor-derived endothelial cells arise from tumor stem-like cells, but the detailed mechanism is not clear. Twist1, an important regulator of epithelial-mesenchymal transition (EMT), has been shown to mediate tumor metastasis and induce tumor angiogenesis. Notch signaling has been demonstrated to be an important player in vascular development and tumor angiogenesis. KLF4 (Krüppel-like factor 4) is a factor commonly used for the generation of induced pluripotent stem (iPS) cells. KLF4 also plays an important role in the differentiation of endothelial cells. Although Twist1 is known as a master regulator of mesoderm development, it is unknown whether Twist1 could be involved in endothelial transdifferentiation of tumor-derived cells. This review focuses on the role of Twist1-Jagged1/Notch-KLF4 axis on tumor-deri...Continue Reading

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
Jan 20, 1995·The Journal of Biological Chemistry·G L Wang, G L Semenza
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y N Jan, L Y Jan
Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Jun 24, 1998·Genes & Development·I Greenwald
Apr 10, 1999·Human Molecular Genetics·Y XueT Gridley
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Jun 15, 1999·Trends in Biochemical Sciences·J Turner, M Crossley
Jul 28, 1999·Chemistry & Biology·M Klagsbrun, M A Moses
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 31, 2000·Molecular Medicine Today·J M Brown
Jan 4, 2001·The International Journal of Biochemistry & Cell Biology·D T DangV W Yang
Jan 19, 2002·Differentiation; Research in Biological Diversity·C MailhosD Ish-Horowicz
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Mar 7, 2003·Genome Biology·Joanna KaczynskiRaul Urrutia
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicholas W GaleGeorge D Yancopoulos
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Mirela AnghelinaNicanor I Moldovan
Jul 19, 2005·Cancer Cell·Ji-Liang Li, Adrian L Harris
Sep 9, 2005·Nature Reviews. Cancer·Thomas BrabletzThomas Kirchner
Sep 17, 2005·Blood·Jennifer O'NeilA Thomas Look
Nov 25, 2005·British Journal of Cancer·A PuisieuxS Ansieau
Dec 16, 2005·Nature·Peter Carmeliet
Dec 24, 2005·Nature Reviews. Cancer·Benjamin D Rowland, Daniel S Peeper
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Jan 28, 2006·European Journal of Cell Biology·Léon C L van Kempen, William P J Leenders
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Apr 26, 2007·Nature Reviews. Cancer·Gavin ThurstonGeorge D Yancopoulos
May 18, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Beth B McConnellVincent W Yang

❮ Previous
Next ❯

Citations

Jun 28, 2017·International Journal of Molecular Sciences·Hong XiangSi-Wen Jiang
Jul 6, 2017·International Journal of Cancer. Journal International Du Cancer·Laura SchirosiAnita Mangia
Jul 10, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linlin ShaoWael El-Rifai
Sep 18, 2020·International Journal of Molecular Sciences·Luís SousaMargarida D Amaral
Jan 21, 2021·Pharmaceutics·Adriana G Quiroz-ReyesElsa N Garza-Treviño
Jul 15, 2021·ACS Applied Materials & Interfaces·Chia-Hao HuangKin Fong Lei

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Takeshi ImamuraYasumichi Inoue
Histology and Histopathology
Jen-Chieh TsengKou-Juey Wu
© 2021 Meta ULC. All rights reserved