Endothelial vasomotor dysfunction in the brachial artery predicts the short-term development of early stage renal dysfunction in patients with coronary artery disease

International Journal of Cardiology
Takamitsu NakamuraKiyotaka Kugiyama

Abstract

This study examined whether endothelial vasomotor dysfunction in the brachial artery predicted early renal dysfunction in patients with coronary artery disease (CAD). Endothelial function in the renal vasculature plays an important role in the regulation of renal hemodynamics. As endothelial dysfunction is a systemic disorder, there may be a relationship between endothelial function in the brachial artery and renal vasculature. Flow-mediated endothelium-dependent dilation (FMD) in brachial artery and renal functional parameters were measured in 757 patients with CAD without macroalbuminuria. In a cross-sectional data, an impaired FMD was associated with higher serum creatinine levels and urinary albumin excretion (UAE), lower creatinine clearance rate and estimated glomerular filtration rate (eGFR) at baseline in multiple linear regression analysis. In a follow-up study including a subgroup of 448 patients with normal renal function (serum creatinine level <1.0mg/dL, UAE <25mg/day and eGFR ≥ 60 mL/min/1.73 m(2) at baseline), 96 patients had an endpoint of early stage renal dysfunction (serum creatinine levels ≥ 1.2mg/dL, UAE ≥ 30 mg/day and/or eGFR <60 mL/min/1.73 m(2)) during 12 month follow-up. Multivariate logistic regressio...Continue Reading

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Citations

Dec 6, 2011·European Journal of Applied Physiology·Kevin S HeffernanJeffrey T Kuvin
Dec 3, 2014·Journal of Vascular Surgery·Karen C ChongS Marlene Grenon
Jun 16, 2015·Internal Medicine·Hirofumi Tomiyama, Akira Yamashina
Mar 5, 2015·Journal of Atherosclerosis and Thrombosis·Tetsuji MochidaKiyotaka Kugiyama
May 18, 2010·Journal of the American Society of Hypertension : JASH·Simona M HogasAdrian Covic
Feb 1, 2013·Transplantation·Dag Olav DahleAnders Asberg
Apr 28, 2012·Journal of Applied Physiology·Kevin K McCully
Mar 28, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Satoru OkaTomoya Nishino
Apr 12, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Bchara SidnawiQianhong Wu
May 28, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Bchara SidnawiQianhong Wu

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