Endothelial YAP1 in Regenerative Lung Growth through the Angiopoietin-Tie2 Pathway.

American Journal of Respiratory Cell and Molecular Biology
Tadanori MammotoAkiko Mammoto

Abstract

Angiogenesis, the formation of new blood capillaries, plays a key role in organ development and regeneration. Inhibition of lung angiogenesis through the blockade of angiogenic signaling pathways impairs compensatory and regenerative lung growth after unilateral pneumonectomy (PNX). The Hippo signaling transducer, Yes-associated protein (YAP) 1 binds to TEA domain transcription factor (TEAD) and controls organ size and regeneration. However, the role of endothelial YAP1 in lung vascular and alveolar morphogenesis remains unclear. In this report, we demonstrate that knockdown of YAP1 in endothelial cells (ECs) decreases angiogenic factor receptor Tie2 expression, and inhibits EC sprouting and epithelial cell budding in vitro and vascular and alveolar morphogenesis in the gel implanted on the mouse lung. The expression levels of YAP1, TEAD1, and Tie2 increase in ECs isolated from the remaining mouse lungs after unilateral PNX and vascular formation is stimulated in the post-PNX mouse lungs. Knockdown of endothelial YAP1 inhibits compensatory lung growth and vascular and alveolar morphogenesis after unilateral PNX. These findings suggest that endothelial YAP1 is required for lung vascular and alveolar regeneration and modulation o...Continue Reading

References

Jul 1, 1994·The Journal of Clinical Investigation·C C HsiaE R Weibel
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M JakkulaS H Abman
Nov 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Maromi K SakuraiMark Puder
May 9, 2008·Nature·Ross J MetzgerMark A Krasnow
Sep 2, 2008·Proceedings of the American Thoracic Society·Troy StevensKurt R Stenmark
Jan 10, 2009·Proceedings of the American Thoracic Society·Jonathan B Orens, Edward R Garrity
Apr 25, 2009·Tissue Engineering. Part a·Blair RoszellChristine M Finck
Mar 8, 2011·Cell·Karin SchlegelmilchFernando D Camargo
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Jul 16, 2011·Annual Review of Cell and Developmental Biology·Alicia S Chung, Napoleone Ferrara
Oct 5, 2011·Angiogenesis·Moritz A KonerdingSteven J Mentzer
May 16, 2012·The Journal of Clinical Investigation·Moritz FelchtHellmut G Augustin
Jun 5, 2012·Trends in Cell Biology·Azucena Ramos, Fernando D Camargo
Jul 17, 2012·Journal of Cell Science·Akiko MammotoDonald E Ingber
Jul 20, 2012·The New England Journal of Medicine·James P ButlerSteven J Mentzer
Aug 29, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joseph CaverzasioCyril Thouverey
Jun 26, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefano PiccoloSirio Dupont
Dec 10, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Kristen ThaneAndrew M Hoffman
May 17, 2014·Differentiation; Research in Biological Diversity·Aadil KaisaniJerry W Shay
Oct 8, 2014·Physiological Reviews·Stefano PiccoloMichelangelo Cordenonsi
Apr 29, 2015·Developmental Biology·Chuwen LinPao-Tien Chuang
May 13, 2015·Nature Communications·Hyun-Jung ChoiYoung-Guen Kwon
Jun 20, 2015·American Journal of Respiratory Cell and Molecular Biology·Tadanori MammotoAkiko Mammoto
Aug 16, 2015·Cell·Hyun Woo ParkKun-Liang Guan
Nov 1, 2016·American Journal of Respiratory Cell and Molecular Biology·Tadanori MammotoAkiko Mammoto
Mar 16, 2017·Development·Christina E BarkauskasBrigid L M Hogan
Mar 30, 2017·Developmental Cell·Hiroyuki NakajimaNaoki Mochizuki
May 24, 2017·Molecular Medicine Reports·Menggang Liu, Ping Chen
Aug 15, 2017·The Journal of Clinical Investigation·Jongshin KimGou Young Koh
Sep 16, 2017·American Journal of Respiratory Cell and Molecular Biology·Tadanori MammotoAkiko Mammoto
Sep 28, 2017·Nature Reviews. Molecular Cell Biology·Tito PancieraStefano Piccolo
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Masahide SakabeMei Xin
Apr 24, 2018·Microvascular Research·Akiko MammotoTadanori Mammoto

❮ Previous
Next ❯

Citations

Apr 21, 2020·American Journal of Respiratory and Critical Care Medicine·Elena A GoncharovaMark T Gladwin
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Boon C HengXuliang Deng
Nov 30, 2019·Frontiers in Bioengineering and Biotechnology·Akiko Mammoto, Tadanori Mammoto
Jun 16, 2021·Development·Laura CurreyMichael Piper
Jun 15, 2021·American Journal of Respiratory and Critical Care Medicine·Erick FornoPaul D Robinson
Oct 19, 2021·Frontiers in Cell and Developmental Biology·Tendai HunyenyiwaAkiko Mammoto

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
transfection
transgenic

Software Mentioned

AngioTool

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.