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Endothelin-1 and α-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways

Pigment Cell & Melanoma Research

Sep 10, 2019

Viki B SwopeZalfa A Abdel-Malek

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Abstract

Human melanocyte homeostasis is sustained by paracrine factors that reduce the genotoxic effects of ultraviolet radiation (UV), the major etiological factor for melanoma. The keratinocyte-derived endothelin-1 (End-1) and α-melanocyte-stimulating hormone (α-MSH) regulate human melanocyte...read more

Mentioned in this Paper

Ataxia Telangiectasia
Malignant Neoplasms
Chromatin
DNA
DNA Damage
DNA-Binding Proteins
Genome
Hormones
Melanocyte
Melanoma
3
5
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Endothelin-1 and α-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways

Pigment Cell & Melanoma Research

Sep 10, 2019

Viki B SwopeZalfa A Abdel-Malek

PMID: 31505093

DOI: 10.1111/pcmr.12823

Abstract

Human melanocyte homeostasis is sustained by paracrine factors that reduce the genotoxic effects of ultraviolet radiation (UV), the major etiological factor for melanoma. The keratinocyte-derived endothelin-1 (End-1) and α-melanocyte-stimulating hormone (α-MSH) regulate human melanocyte...read more

Mentioned in this Paper

Ataxia Telangiectasia
Malignant Neoplasms
Chromatin
DNA
DNA Damage
3
5

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