PMID: 8944823Nov 1, 1996Paper

Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart

Cardiovascular Research
E Bugge, K Ytrehus

Abstract

Protection from ischaemic preconditioning (IP) is dependent on activation of protein kinase C (PKC), and preconditionings protection can be mimicked by stimulation of various membrane receptors which are known to activate PKC. It is well known that KATP channel activation is cardioprotective. We tested the hypothesis that preischaemic treatment with endothelin-1 (ET-1) can protect against infarction by a PKC-dependent mechanism and by activating KATP channels. Buffer-perfused isolated rat hearts were subjected to 30 min regional ischaemia and 120 min reperfusion. Risk zone was determined by fluorescent particles, and infarct size by TTC staining. Treatment with ET-1 in a dose of 1 nM prior to ischaemia significantly reduced infarct size in % of the risk zone compared to the control group (infarct size: 14.1 +/- 2.6 vs. 41.9 +/- 3.4%), while ET-1 0.1 nM did not protect (infarct size: 40.9 +/- 3%). AS the protective dose of ET-1 resulted in a significant reduction of coronary flow, a control group with a similar preischaemic flow-reduction was included (infarct size: 48.1 +/- 4.2%). Both the nonselective ETA/ETB receptor antagonist bosentan (1 microM) and the ET(A)-receptor-selective antagonist BQ 123 (2 microM) abolished protect...Continue Reading

Citations

Apr 14, 2011·Fukushima Journal of Medical Science·Kazuhiko NakazatoYukio Maruyama
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·R TianJ S Ingwall
Dec 17, 2009·The Journal of Surgical Research·Hui-min LiuZhengyuan Xia
May 9, 2009·British Journal of Pharmacology·S K WalshC L Wainwright
Jun 1, 2005·Vascular Pharmacology·Stuart D CritzJames M Downey
Jul 2, 2009·Autonomic & Autacoid Pharmacology·S K WalshC L Wainwright
Nov 1, 2003·Antioxidants & Redox Signaling·Yuichiro J Suzuki
Nov 28, 2017·Cellular and Molecular Neurobiology·Eric J KnottNicolas G Bazan
Nov 14, 2000·Circulation Research·B O'Rourke
Apr 27, 2002·Heart Disease·Boris Z SimkhovichRobert A Kloner
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Peter S FischbachBenedict R Lucchesi
Jun 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Zhengyuan XiaDavid M Ansley
Nov 28, 2002·Clinical and Experimental Immunology·A TachibanaA Morikawa

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