PMID: 2115743Jul 1, 1990Paper

Endothelin 1 causes pulmonary vasodilation in rats

The American Journal of Physiology
K HasunumaI F McMurtry

Abstract

Endothelin 1 (ET-1), a peptide produced by endothelial cells, causes transient dilation of some systemic vascular beds. To test whether low concentrations of ET-1 could also dilate the pulmonary vascular bed, we examined its effects in isolated blood- and salt solution-perfused rat lungs and in conscious catheterized rats. In blood-perfused lungs undergoing hypoxic (3% O2) vasoconstriction, repeated additions of 0.5 nM ET-1 to the perfusate elicited transient partial vasodilations. The higher concentration of 5 nM caused a larger transient vasodilation followed by vasoconstriction. In nine conscious rats exposed to 8% O2, intravenous ET-1 (0.2 nmol/kg) reversed the hypoxic pressor response by 63 +/- 8% without affecting cardiac output. In eight salt solution-perfused lungs vasoconstricted with 25 mM KCl, 0.5 nM ET-1 caused a maximum vasodilation of 35 +/- 3% with a half-life of 10.7 +/- 1.1 min. The vasodilation was not inhibited by blockers of cyclooxygenase (3.1 microM meclofenamate), platelet-activating factor receptors (10 microM Web 2086), histamine H1 receptors (50 microM chlorpheniramine), or endothelium-derived relaxing factor activity (10 microM hemoglobin and 50 microM methylene blue). However, it was reduced by appro...Continue Reading

Citations

Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·K SatoI F McMurtry
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·D IvyS H Abman
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Q LiuJ T Sylvester
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J A Madden
Sep 23, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D D IvyS H Abman
Mar 11, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xin Qing, Ingegerd M Keith
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·B ThébaudA T Dinh-Xuan
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·D Dunbar IvyIvan F McMurtry
Mar 4, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tom P RobertsonJeremy P T Ward
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R M Kedzierski, M Yanagisawa

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