Endothelin-1 in the tumor microenvironment correlates with melanoma invasion

Melanoma Research
Luis ChiribogaSumayah Jamal

Abstract

Endothelin-1 (ET-1) is a vasoactive peptide that also plays a role in the tanning response of the skin. Animal and cell culture studies have also implicated ET-1 in melanoma progression, but no association studies have been performed to link ET-1 expression and melanoma in humans. Here, we present the first in-vivo study of ET-1 expression in pigmented lesions in humans: an ET-1 immunohistochemical screen of melanocytic nevi, melanoma in situ lesions, invasive melanomas, metastatic melanomas, and blue nevi was performed. Twenty-six percent of melanocytic nevi and 44% of melanoma in situ lesions demonstrate ET-1 expression in the perilesional microenvironment, whereas expression in nevus or melanoma cells was rare to absent. In striking contrast, 100% of moderately to highly pigmented invasive melanomas contained numerous ET-1-positive cells in the tumor microenvironment, with 79% containing ET-1-positive melanoma cells, confirmed by co-staining with melanoma tumor marker HMB45. Hypopigmented invasive melanomas had reduced ET-1 expression, suggesting a correlation between ET-1 expression and pigmented melanomas. ET-1-positive perilesional cells were CD68-positive, indicating macrophage origin. Sixty-two percent of highly pigment...Continue Reading

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Citations

Mar 14, 2018·International Journal of Oncology·Giulia C LeonardiMassimo Libra
Sep 29, 2020·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yijun XiaDongsheng Cao
Oct 10, 2020·Molecular Biology Reports·Marveh RahmatiMohammad Amin Moosavi
Jan 13, 2021·International Journal of Molecular Sciences·Justyna MazurkiewiczDorota Nowak
Mar 27, 2021·The British Journal of Oral & Maxillofacial Surgery·A SayanV Ilankovan
Jun 23, 2021·Curēus·Matthew G DaveyNiall M McInerney

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Methods Mentioned

BETA
xenografts
dot-blot
biopsy
biopsies

Software Mentioned

SPSS

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