PMID: 8587361Jan 1, 1995Paper

Endothelin-1-induced contraction and relaxation of isolated rat basilar artery: effect of the endothelium

Journal of Cardiovascular Pharmacology
L SchillingM Wahl

Abstract

In rat basilar artery ring segments precontracted with prostaglandin (PG)F2a, endothelin (ET)-3 induced a concentration-related relaxation at doses of 3 x 10(-10) to 1 x 10(-8) M, whereas contraction occurred at higher concentrations. In contrast, relaxation by ET-1 was observed only in the presence of an ETA receptor antagonist. The ET-induced relaxation could be blocked by an ETB receptor antagonist and by a nitric oxide (NO) synthase inhibitor, suggesting activation of an ETB receptor. This receptor, which may be located on the endothelium, is apparently coupled to release of NO. Under resting tension, ET-1 and ET-3 induced concentration-related contractions, which were enhanced after NO synthase inhibition or after de-endothelialization. These results suggest simultaneous induction of contraction and relaxation by the ETs. With ET-1, this occurs in the same concentration range, with the relaxing effect being masked by the contraction.

Citations

Jan 1, 1997·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G I FegerM Wahl
Aug 23, 2001·Pharmacology & Therapeutics·P W Hadoke
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kamakshi SachidanandamAdviye Ergul
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alex K HarrisAdviye Ergul
Nov 19, 2013·Investigative Ophthalmology & Visual Science·Luke B PottsTravis W Hein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.