Endothelin-1-induced contraction of pulmonary arteries from endotoxemic rats is attenuated by the endothelin-A receptor antagonist, BQ123

Critical Care Medicine
N P CurzenT W Evans

Abstract

Sepsis is characterized by systemic vasodilation and hyporesponsiveness to constrictor agents, at a time when the pulmonary circulation exhibits varying degrees of vasoconstriction. Plasma endothelin-1 concentrations are increased, but the role of this potent vasoconstrictor peptide in modulating the vascular response to sepsis is unknown. Therefore, we assessed the effect of endothelin-A receptor antagonism in the response of pulmonary arteries from rats treated with lipopolysaccharide to endothelin-1, and determined the vasomotor role of the endothelin-B receptors that are known to be located on rat pulmonary artery smooth muscle and endothelium. Prospective, controlled study. Animal research laboratory. Male Wistar rats (275 to 300 g). Animals were injected with either lipopolysaccharide (20 mg/kg i.p.) or saline (1 mL i.p.) 4 hrs before being killed. The main pulmonary arteries were cut into 2-mm rings, and suspended in an organ bath. In the first set of experiments, half of the rings underwent a procedure that removed the endothelium, and the contractile response to cumulative doses of endothelin-1 (10(-11) to 10(-6) M) was measured. Half of the rings were pretreated with the endothelin-A receptor antagonist, BQ123 (10(-5)...Continue Reading

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Citations

Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Apr 28, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S IshimaruY Hirata
Aug 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierTom H M Hasaart
May 2, 2014·Life Sciences·Brandi D FreemanMahalia S Desruisseaux
Jul 23, 2003·Anesthesia and Analgesia·Greg Stratmann, George A Gregory
Jun 20, 2019·International Journal of Molecular Sciences·Adrian M PiliponskyNicholas J Shubin

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