PMID: 8587386Jan 1, 1995Paper

Endothelin-1-induced downregulation of ETB receptor mRNA: participation of cAMP

Journal of Cardiovascular Pharmacology
S AsadaK Goto

Abstract

In this study we examined the participation of cAMP formation in endothelin-1 (ET-1)-induced downregulation of ETB receptor mRNA in ROS 17/2 rat osteosarcoma cells. Dibutyryl cAMP induced downregulation of ETB receptor mRNA in a time-dependent manner. ET-1 induced production of inositol phosphates and an increase of cAMP level in ROS 17/2 cells. A stimulatory effect on cAMP level was also observed when A23187 plus PMA was added to the cells. The increase in cAMP level induced either by ET-1 or by A23187 plus PMA was inhibited by indomethacin. The downregulation of ETB receptor mRNA induced by ET-1 was significantly inhibited by indomethacin. These results suggest that the ET-1-induced downregulation of ETB receptor mRNA in ROS 17/2 cells may be partly mediated through the increase in cAMP level secondary to the activation of the phosphoinositide hydrolysis/Ca2+ transduction cascade.

Citations

Oct 21, 2000·Biochimica Et Biophysica Acta·R MauschitzG Desoye
May 26, 2005·Brain Research. Brain Research Reviews·Lyle W Ostrow, Frederick Sachs
Mar 15, 1997·Journal of Neuroscience Research·H HamaK Goto
Jun 16, 2000·The Journal of Physiology·H MorawietzJ Holtz

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