PMID: 9186841May 1, 1997Paper

Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors

Journal of Hepatology
B ZhangB Weill

Abstract

We investigated which endothelin receptors mediate the vasoconstrictive effects of endothelin-1 on liver circulation. An isolated perfused rat liver model in recirculation was used. The perfusion of 10(-10) M endothelin-1 had no significant influence on the liver flow, whereas 10(-9) M endothelin-1 induced significant vasoconstriction, with flow dropping from 3.20 +/- 0.34 to 1.48 +/- 0.28 ml. min-1.g-1 liver tissue (p < 0.01 vs controls). The liver flow was interrupted following the perfusion of 10(-8) M endothelin-1. Sarafatoxin C and BQ 3020, two agonists of ETB receptor, had vasoconstrictive effects in this model. Sarafatoxin C decreased the liver flow in a dose-dependent manner, from 3.32 +/- 0.21 to 2.18 +/- 0.20, 1.60 +/- 0.09, and 1.01 +/- 0.06 ml.min-1. g-1, respectively, with 10(-9) M, 10(-8) M, and 10(-7) M. While BQ 123, an antagonist of ETA receptor, or BQ 788, an antagonist of ETB receptor, partially reversed the effect of 10(-9) M endothelin-1, the simultaneous administration of BQ 123 and BQ 788 completely reversed these effects. These results indicate that the vasoconstrictive effects of endothelin-1 on the liver circulation are mediated through both ETA and ETB receptors.

References

Mar 3, 1992·Biochemical Pharmacology·C JouneauxS Lotersztajn
Jan 1, 1991·Journal of Cardiovascular Pharmacology·J G FilepP Sirois
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L FriedmanG Yamasaki
Jan 1, 1991·The Journal of Clinical Investigation·C Serradeil-Le GalS Lotersztajn
Sep 1, 1991·The Journal of Clinical Investigation·S KourembanasD V Faller
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarteauR Poupon
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G J GoresN F LaRusso
Dec 1, 1974·Journal of Applied Physiology·F W OssenbergJ P Benhamou
Aug 10, 1995·The New England Journal of Medicine·E R Levin
Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo
Feb 15, 1995·Biochemical and Biophysical Research Communications·D C Rockey
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L GerbesJ H Henriksen
Nov 30, 1994·Biochemical and Biophysical Research Communications·H KarakiM Hori
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·K IshikawaT Nagase
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OkumuraT Kashiwagi
Aug 15, 1993·Archives of Biochemistry and Biophysics·C R GandhiM S Olson
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E BluhmK F Badr
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C HoussetD M Bissell
Mar 8, 1993·FEBS Letters·T A Tran-ThiK Decker
Apr 1, 1993·The Journal of Clinical Investigation·M OshitaH Fusamoto
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C Rockey, R A Weisiger

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Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SogniD Lebrec
May 16, 2002·Journal of Cellular Physiology·Rong Shao, Don C Rockey
Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N NagasueT Harada
Mar 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hong-Qiang FengDon C Rockey
Sep 22, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vinzent N SpetzlerMarkus Selzner
Apr 17, 2004·European Journal of Clinical Investigation·C-C ChanS-D Lee
Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicolas GoldaracenaMarkus Selzner
Jan 10, 2001·Bone Marrow Transplantation·J F TomisJ M Fernández-Rañada
Jul 16, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sandra M MerkelMark G Clemens
Jun 19, 2002·Cardiovascular Drug Reviews·Megumu Okada, Masaru Nishikibe
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T NishidaH Matsuda
Jul 6, 2000·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·L G Thaete, M G Neerhof

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