Endothelin-1 inhibits inward rectifier potassium channels and activates nonspecific cation channels in cultured endothelial cells

Pharmacology
H ZhangE E Daniel

Abstract

A predominant inward rectifier and a small outward potassium current were obtained in whole-cell patch-clamp recordings from cultured bovine pulmonary arterial endothelial cells. Application of endothelial-1 (ET-1; 10-100 nmol/l) inhibited the inward rectifier. Washout with bath solution did not recover the current decreased by ET-1. In cell-attached studies, ET-1 (1 nmol/l) inhibited single-channel activity of the inward rectifier and in some patches enhanced activity of the outward potassium current without change of conductance. A non-specific cation current which is permeable to calcium was identified in cell-attached patches in cultured human umbilical vein endothelial cells. ET-1 (1 nmol/l) increased activity of the nonspecific cation channel. ET-1 may increase calcium influx into endothelial cells and promote synthase and release of endothelium-derived factors.

Citations

Apr 1, 1995·Pflügers Archiv : European journal of physiology·E WischmeyerA Karschin
May 1, 1995·Canadian Journal of Physiology and Pharmacology·E E DanielC Y Kwan
Jan 1, 1997·Annual Review of Physiology·B NiliusG Droogmans
Feb 4, 2016·The Journal of Physiology·Swapnil K SonkusareMark T Nelson
Feb 22, 2012·Reproductive Sciences·Wattana B WatanapaKitirat Techatraisak
Aug 12, 2016·Physiology·Kristin A Gerhold, Martin A Schwartz
May 8, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Wolfram ScharbrodtJohannes Wiecha
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Yun DaiJohn H Zhang
Oct 3, 2001·Physiological Reviews·B Nilius, G Droogmans

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