PMID: 8950725Jan 1, 1996Paper

Endothelin-1-like immunoreactivity and endothelin receptors in the human placenta from normotensive and hypertensive pregnancies

Journal of Perinatal Medicine
M HasegawaK Nakao

Abstract

The levels of endothelin-1-like immunoreactivity (ET-1-LI) and characteristics of endothelin receptors in the chorionic villous tissue of human placenta were determined. The ET-1-LI level in chorionic villous tissue obtained from normal term placenta was 2,450 +/- 940 pg/g wet weight (mean +/- SD, n = 4). Further analysis using gel permeation chromatography and reverse-phase high performance liquid chromatography showed that the main ET-1-LI constituent of ET-1-LI in this tissue was ET-1. Scatchard analysis of [125I]ET-1 binding to the membrane fraction of chorionic villous tissue obtained from term placenta showed high affinity receptor sites with an apparent dissociation constant (Kd) of 23.6 +/- 11.1 pM and a Bmax value of 388 +/- 238 fmol/mg protein (n = 5). The same binding study with [125I]ET 3 showed a Kd of 13.9 +/- 3.8 pM and a Bmax value of 176 +/- 78 fmol/mg protein (n = 5). These results suggest that both ET-A and ET-B receptors (ET-AR and ET-BR) are expressed in chorionic villous tissue. This finding was further confirmed by Northern blot analysis showing the expression of both ET-AR and ET-BR mRNAs in this tissue. ET-1-LI in the umbilical venous plasma of the newborns from women with pregnancy-induced hypertension...Continue Reading

References

Oct 1, 1992·British Journal of Obstetrics and Gynaecology·A BenigniG Remuzzi
Mar 1, 1992·American Journal of Obstetrics and Gynecology·B A ClarkF H Epstein
Feb 1, 1992·American Journal of Obstetrics and Gynecology·E SchiffS Mashiach
Jul 15, 1991·Biochemical and Biophysical Research Communications·Y OgawaH Imura
Aug 5, 1991·FEBS Letters·K HosodaH Imura
Dec 1, 1991·Acta Physiologica Scandinavica·A HemsénJ M Lundberg
Dec 1, 1990·The Journal of Experimental Medicine·H EhrenreichA S Fauci
Feb 1, 1991·Journal of Cardiovascular Pharmacology·G R Li, G R Ferrier
Dec 1, 1991·American Journal of Obstetrics and Gynecology·D S MastrogiannisR Benoit
Sep 1, 1991·American Journal of Obstetrics and Gynecology·A NovaM D Mitchell
Apr 1, 1990·American Journal of Obstetrics and Gynecology·R A WordM L Casey
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R N TaylorJ M Roberts
Nov 22, 1990·The New England Journal of Medicine·K KamoiT Yamaji
Jan 18, 1990·The New England Journal of Medicine·C J Murray
Jan 2, 1990·Molecular and Cellular Endocrinology·K P SunnergrenM L Casey
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A InoueT Masaki
May 1, 1989·The Journal of Clinical Investigation·V KonI Ichikawa
May 15, 1985·American Journal of Obstetrics and Gynecology·B J TrudingerC M Cook
Oct 1, 1993·Obstetrics and Gynecology·R H Schwarz

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