Abstract
Endothelin-1 (ET-1) is a vasoconstrictor produced by vascular endothelial cells and may play a role in risk for development of coronary artery disease (CAD) and heart failure (HF). In a cohort of 1084 patients referred for coronary angiography, we investigated cross-sectional associations between ET-1 concentrations and prevalent CAD, as well as value of ET-1 for prognostication of future cardiovascular events. Associations between ET-1 and presence/severity of CAD were assessed. Patients were followed for a median of 4 years for outcomes including incident HF, myocardial infarction (MI), cardiovascular mortality, and all-cause mortality. The median concentration of ET-1 was 2.57 ng/L. Patients with ET-1 concentrations above the median were more likely to have higher risk clinical features. Among those without prevalent MI at presentation, ET-1 concentrations were not associated with presence or severity of CAD. In adjusted Cox proportional hazards analyses, log-transformed ET-1 concentrations predicted incident HF [hazard ratio (HR) = 1.51 per increase in log-SD; 95% CI, 1.06-2.15; P = 0.02] and all-cause mortality (HR = 1.61 per increase in log-SD; 95% CI, 1.03-2.53; P = 0.04). Concentrations of ET-1 above the median were ass...Continue Reading
References
May 1, 1985·The American Journal of Physiology·K A HickeyR F Highsmith
Feb 16, 2006·Archives of Internal Medicine·James L JanuzziDonald M Lloyd-Jones
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Markus P SchneiderDavid M Pollock
Jul 10, 2007·Cardiovascular Research·Felix Böhm, John Pernow
May 4, 2010·American Heart Journal·Ingo EitelHolger Thiele
Jul 31, 2010·Journal of Cardiac Failure·W H Wilson TangRichard W Troughton
Nov 17, 2011·Clinical Chemistry·Roland R J van Kimmenade, James L Januzzi
Aug 28, 2012·Circulation·Kristian ThygesenShanti Mendis
Oct 8, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Agata KowalczykAnna Goraca
Dec 30, 2014·Clinical Biochemistry·Stephen S GottliebDavid S Krantz
Nov 14, 2015·PloS One·Ping QingJian-Jun Li
Nov 18, 2015·BMC Cardiovascular Disorders·Bledar DakaUlf Lindblad
Jul 22, 2016·JAMA Cardiology·Matthew D JankowichGaurav Choudhary
Nov 26, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yao WangJian-Jun Li
Apr 30, 2017·JACC. Heart Failure·Milton PackerUNKNOWN ENABLE Investigators and Committees
Jul 29, 2017·Cell·Rajat M GuptaSekar Kathiresan
Mar 21, 2018·Circulation. Genomic and Precision Medicine·C Mary SchoolingLuisa N Borrell
Citations
Apr 18, 2019·Coronary Artery Disease·Fang WangXi Chen
Nov 5, 2019·Hypertension·Matthias Barton, Masashi Yanagisawa
May 10, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Ping LiSushrut S Waikar
Jan 24, 2021·Heart and Vessels·Masanao NayaNagara Tamaki
Sep 9, 2021·Hormone Molecular Biology and Clinical Investigation·Saeideh AksehAhmadreza Jodati