PMID: 16641652Apr 28, 2006Paper

Endothelin-1-mediated inflammation in acute renal failure

Critical Care Nursing Quarterly
Allan D Angerio

Abstract

Acute renal failure presents a serious and life-threatening problem in hospitalized patients. Current therapies address the systemic alterations in renal failure. Cellular changes also occur. These changes affect the glomerular filtration rate and the integrity of the glomerular membrane. ET-1, the most potent vasoconstrictor known, has a negative effect on both the rate of filtration and the integrity of the filtering membrane in renal failure. Using ET-1 antagonists along with the current therapies may prove useful in patients.

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Citations

Nov 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephanie W Watts

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