Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study in newborn lambs

Early Human Development
M de VroomenF van Bel

Abstract

Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P(ap)) during RDS may give insight in the role of ET-1. ET-1 and P(ap) changes were studied in an experimental model of RDS, induced by lung lavages in seven newborn lambs. Five other lambs served as controls. Lung lavages induced a twofold increase of mean P(ap) (from 15 to 34 mm Hg) that remained present throughout the 4-h study period. Along with the increased P(ap), ET-1 plasma concentration showed a significant increase 15 min after induction of RDS at all three sample locations (pulmonary artery 198%, aorta 181% and right atrium 195% compared to baseline). This increased concentration remained high at 1 and 4 h of RDS. In control animals, no significant changes in ET-1 concentrations were observed. Plotting ET-1 concentration values against mean P(ap), in RDS and control animals at all time points, a correlation was found between the severity of the pulmonary hypertension and ET-1 concentratio...Continue Reading

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Citations

Apr 20, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Michael J StarkVicki Clifton
May 9, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mohamed Fahmy Elnoamany, Ashraf Abdelraouf Dawood
Sep 3, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C W BenjaminR S Procianoy
Oct 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason GienSteven H Abman
Dec 18, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·David WolfJason Gien
Oct 24, 2017·World Journal of Pediatrics : WJP·Niralee BabooaChao Chen
Jul 7, 2021·Journal of Veterinary Internal Medicine·Merve IderMuhammed M Kapar

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