PMID: 9547903Apr 21, 1998Paper

Endothelin-1 production by human synoviocytes

Annals of Clinical Biochemistry
H YoshidaJ Horiuchi

Abstract

Immunoreactive (ir)-endothelin (ET)-1 concentrations in serum samples and synovial fluids from patients with rheumatoid arthritis were higher than concentrations in sera obtained from healthy volunteers. No significant difference in ir-ET-1 concentrations in synovial fluid was observed between rheumatoid arthritis patients and osteoarthritis patients. Cultured fluids of synovial cells collected from synovial tissues and leucocytes from synovial fluids of rheumatoid arthritis patients were studied to determine the origin of ir-ET-1 in synovial fluids. Ir-ET-1 was detected in the cultured fluids of synovial macrophage-like type A cells, but not in those of fibroblast-like type B cells from the synovial tissues or leucocytes from the synovial fluids. Longitudinal studies showed that the ir-ET-1 concentration in the cultured fluid reached a peak around 24 h after starting the culture. ET-1 secreted from macrophage-like synoviocytes may be involved in the pathogenesis of inflammatory arthritis.

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Citations

Dec 21, 2002·American Journal of Veterinary Research·Jorge de la CalleRustin M Moore
Jul 30, 2008·Endothelium : Journal of Endothelial Cell Research·Vasileios F PanoulasGeorge D Kitas
Jun 8, 2013·The EPMA Journal·Josef FlammerAndreas J Flammer
Mar 5, 2004·The Journal of Pharmacology and Experimental Therapeutics·Stephen J GettingMichele D'Amico
Jan 18, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Paula B DonateFernando Q Cunha
Jan 19, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Katarzyna KonieczkaJosef Flammer
Jun 3, 2008·Journal of Leukocyte Biology·Fernando de Paiva ConteMaria das Graças M O Henriques
Nov 21, 2020·Current Rheumatology Reviews·Janis MednieksJurgis Skilters

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