Endothelin-1 regulates tone of isolated small arteries in the rat: effect of hyperendothelinemia

Hypertension
E ThorinJocelyn Dupuis

Abstract

Chronic elevation of plasma endothelin-1 (ET-1) levels has been reported in several pathological conditions. To investigate the consequences of increased circulating ET-1 on vascular responsiveness, Sprague-Dawley rats (n=16) were chronically instrumented with a minipump delivering ET-1 at a constant dose for 7 days. Plasma ET-1 levels were more than doubled in treated (0.98+/-0.09 pmol/L; P<.05) versus untreated sham-operated rats (0.43+/-0.04 pmol/L), whereas systolic arterial blood pressure increased (139+/-5 versus 128+/-4 mm Hg in untreated rats; P<.05). After rats were killed, segments of middle cerebral (MCA) and mesenteric (MES) arteries were mounted on an isometric myograph. ET-induced contraction was shifted to the right in ET-1-treated animals and not modified by BQ123 (an ET(A) receptor antagonist); bosentan (ET(A/B) receptor antagonist) prevented ET-1-induced contraction in both groups. After inhibition of nitric oxide synthase with N(omega)-nitro-L-arginine (L-NNA), both phenylephrine and oxymetazoline (an alpha2-adrenoceptor agonist) induced MCA contraction. The sensitivity to phenylephrine was decreased in ET-1-treated compared with control rats (P<.05). Sensitivity to phenylephrine-induced contraction was decre...Continue Reading

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Citations

Dec 8, 2009·Pflügers Archiv : European journal of physiology·Eric Thorin, David J Webb
Jun 10, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Atman P ShahJames T Niemann
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ChenM Spatz
Apr 25, 2000·Journal of Cardiovascular Pharmacology·J WidderL Schilling
Sep 26, 2003·Journal of Cardiovascular Pharmacology·Patricia Gilbert, Eric Thorin
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Annik MigneaultJocelyn Dupuis
Nov 5, 2003·British Journal of Pharmacology·Eric ThorinAngelino Calderone
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·E ThorinJ Dupuis
Jan 1, 2014·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Patrícia de S RossignoliAgnaldo B Chies

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