Endothelin-1 serum levels correlate with MCP-1 but not with homocysteine plasma concentration in patients with systemic sclerosis

Scandinavian Journal of Rheumatology
D PeterlanaC Lunardi

Abstract

To determine whether homocysteine (Hcy) plasma levels are correlated with molecules indicative of endothelial cell and fibroblast activation, including endothelin-1 (ET-1) and monocyte chemoattractant protein-1 and -3 (MCP-1, MCP-3), in patients with systemic sclerosis (SSc). Eighty-two patients were enrolled in this study; the control group included 75 age- and sex-matched subjects. Plasma Hcy was determined by high-performance liquid chromatography; folic acid, and vitamin B(12) plasma levels were determined by a chemiluminescence method. ET-1, MCP-1, and MCP-3 were determined by enzyme-linked immunosorbent assay (ELISA). Analysis of the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene was performed by polymerase chain reaction (PCR) and digestion with the enzyme HinfI. Hcy levels were lower in patients whereas ET-1 was significantly higher in patients and correlated with MCP-1. Stratification of the patients on the basis of Hcy levels was not associated with any statistical difference in the concentration of ET-1, MCP-1, and MCP-3. Patients with diffuse disease presented the highest levels of ET-1 and MCP-1. The distribution of the MTHFR genotypes was not different in patients and controls. In SSc, H...Continue Reading

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Citations

Nov 7, 2012·Indian Dermatology Online Journal·Mehrdad AghaeiMahdieh Shojaa
Dec 25, 2015·Current Rheumatology Reports·Giuseppina Stifano, Romy Beatriz Christmann
Aug 20, 2009·Autoimmunity Reviews·Pietro Enea LazzeriniFranco Laghi Pasini
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Nov 10, 2021·Immunity, Inflammation and Disease·Pardis-Sadat Tabatabaei-PanahReza Akbarzadeh

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