Endothelin-3-induced relaxation of isolated rat basilar artery is mediated by an endothelial ETB-type endothelin receptor

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
L SchillingM Wahl

Abstract

The endothelin (ET) receptor mediating relaxation of cerebral arteries was characterized using ring segments obtained from the rat basilar artery. Under resting tension, ET-3 (> 10(-8) M) but not the specific ETB receptor agonist IRL 1620 induced contraction. In ring segments precontracted with 3 x 10(-6) M prostaglandin (PG) F2 alpha, ET-3 (10(-12) - 10(-8) M) and IRL 1620 (10(-14) - 10(-6) M) induced concentration-related relaxation. IRL 1620 was more potent than ET-3, the pD2 (-log10EC50) values being 10.002 +/- 0.751 (mean +/- SD) for IRL 1620 and 8.836 +/- 0.415 for ET-3. Relaxation was abolished after preincubation with the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine (10(-5) M) as well as in segments devoid of a functionally intact endothelium. At a concentration above 10(-8) M, ET-3 resulted in a further increase of PGF2 alpha-induced contraction that was not observed with IRL 1620. The presumably specific ETB receptor antagonist IRL 1038 (10(-7) - 3 x 10(-6) M) diminished or even abolished (3 x 10(-6) M) the relaxation induced by ET-3 or IRL 1620. IRL 1038 did not exert any vasomotor effect by itself, and it did not significantly affect ET-3-induced contraction. These results indicate that in the rat isolat...Continue Reading

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·S MorelandJ T Hunt
Apr 1, 1992·Neuron·O ManzoniL Fagni
Apr 30, 1992·Biochemical and Biophysical Research Communications·M TakaiT Okada
May 1, 1992·Journal of Medicinal Chemistry·A M Doherty
Apr 1, 1990·The International Journal of Neuroscience·A AngeliR Carignola
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G I FegerM Wahl
Mar 1, 1994·Journal of Cellular Physiology·M S GoligorskyW F Bahou
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KobariH Takeda
Jul 1, 1993·British Journal of Pharmacology·J B SalomE Alborch
Jun 1, 1993·Trends in Pharmacological Sciences·W G HaynesD J Webb

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Citations

Jan 1, 1997·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G I FegerM Wahl
Jul 4, 1998·European Journal of Pharmacology·N FernándezG Diéguez
Sep 15, 1998·Kidney International. Supplement·C GörlachM Wahl
Apr 3, 2003·Clinical Neuropharmacology·Hartmut VatterVolker Seifert
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O TouzaniJ McCulloch
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C GörlachM Wahl
Apr 25, 2000·Journal of Cardiovascular Pharmacology·J WidderL Schilling
Aug 17, 2002·Neurosurgery·Hartmut VatterLothar Schilling
Apr 7, 2007·Journal of Neurosurgery·Nobutake SadamasaNobuo Hashimoto
May 6, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jeffrey J IliffG Alexander West
Aug 31, 2006·Cardiovascular Drug Reviews·Hartmut Vatter, Volker Seifert
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·Aarati RaiAnil Gulati
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·M ZuccarelloR M Rapoport
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Julien ChuquetOmar Touzani
Feb 14, 2018·Stroke; a Journal of Cerebral Circulation·Hanhan LiuNicole A Terpolilli
Aug 1, 1996·Canadian Journal of Physiology and Pharmacology·A M Sharifi, E L Schiffrin
Feb 10, 1999·The American Journal of Physiology·T IwasakiM Nakajima
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad

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