Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy

Journal of Vascular Research
Magnus SettergrenMajid Kalani

Abstract

Endothelin-1 levels are elevated in patients with type 2 diabetes mellitus and may contribute to impaired microvascular function. We investigated the effect of selective endothelin-A (ET(A)) receptor blockade (BQ123) on skin microcirculation in patients with type 2 diabetes and albuminuria. Ten type 2 diabetes patients and 8 non-diabetic controls were investigated. Nutritive skin capillary circulation, investigated by videophotometric capillaroscopy, and total skin microcirculation, assessed by laser Doppler flux-metry (LDF), were studied during intra-arterial infusion of saline for 15 min, followed by BQ123 infusion for 60 min. Following BQ123 infusion there was a significant increase in resting capillary blood cell velocity (CBV) in patients with type 2 diabetes from 0.24 (0.20-0.34) mm/s at baseline to 0.61 (0.46-0.88) mm/s at 60 min, but no significant change in the control subjects [0.55 (0.10-0.68) vs. 0.38 (0.13-0.88) mm/s; p < 0.005 for difference between groups]. Peak CBV following arterial occlusion and skin temperature increased significantly in the type 2 diabetes group but not in the control group during BQ123 infusion. There were no significant changes in LDF parameters during infusion of BQ123 in either group. ET...Continue Reading

References

Sep 1, 1975·Microvascular Research·M IntagliettaW R Tompkins
May 1, 1990·Diabetologia·K TakahashiS R Bloom
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·K HirataY Noda
Aug 10, 1995·The New England Journal of Medicine·E R Levin
May 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C LetiziaA Iannacone
Sep 27, 2000·Journal of Diabetes and Its Complications·J E Tooke
Oct 6, 2001·Foot & Ankle International·E J BoykoV L Stensel
Apr 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Felix BöhmJohn Pernow
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Zia Ali Khan, Subrata Chakrabarti
Nov 25, 2003·Diabetes·J Robinson SingletonEva L Feldman
Nov 1, 2005·Journal of Pharmacological and Toxicological Methods·C I WrightR Draijer

❮ Previous
Next ❯

Citations

Apr 19, 2011·Journal of Medical Case Reports·Fátima Alvarez ReyesManuel Brito Suárez
Jun 15, 2014·Pharmacology & Therapeutics·Dimitris TousoulisChristodoulos Stefanadis
Mar 9, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Janice C Tsui, Xu Shi-Wen
Feb 8, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fernando Rodríguez-PascualSantiago Lamas
Feb 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Adviye Ergul
Dec 28, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Ritchie, Mark Sullivan
Apr 10, 2012·Life Sciences·John PernowFelix Böhm
Apr 21, 2016·Cardiovascular Diabetology·Nikolaos Östlund PapadogeorgosMajid Kalani
Apr 23, 2016·The International Journal of Biochemistry & Cell Biology·Simona-Adriana ManeaAdrian Manea
Jun 24, 2014·European Journal of Pharmacology·Suzanne A Nasser, Mahmoud M El-Mas
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·John LekakisCharalambos Vlachopoulos
Sep 16, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michail E KeramidasOla Eiken

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.