Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension

European Journal of Pharmacology
J C Wanstall, S R O'Donnell

Abstract

Contractile responses to endothelin, 5-hydroxytryptamine (5-HT), noradrenaline and potassium were obtained on isolated preparations of pulmonary artery from rats made pulmonary hypertensive by an injection of monocrotaline (105 mg/kg s.c.) 4 weeks previously. When compared with data obtained in control rats, the potencies (negative log EC50 values) for 5-HT, noradrenaline and potassium were increased (30, 3- and 3-fold, respectively), and the maximum contractions (mN/mm2) to endothelin, noradrenaline and potassium were reduced (65, 40 and 45% reduction). These changes were not seen 2 weeks after injection of monocrotaline, before pulmonary hypertension developed, or in preparations of aorta. It is concluded that monocrotaline-induced pulmonary hypertension affects pulmonary vascular responsiveness to spasmogens differentially. The comparative importance of endothelin and 5-HT as pulmonary vasoconstrictors may change in monocrotaline-induced pulmonary hypertension, there being an increase in responsiveness to 5-HT and a decrease in responsiveness to endothelin.

References

Aug 1, 1986·British Journal of Pharmacology·J A AngusK Satoh
Jan 17, 1989·European Journal of Pharmacology·J C Wanstall, S R O'Donnell

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Citations

May 6, 1996·European Journal of Pharmacology·J C Wanstall, E O'Brien
Oct 2, 2003·European Journal of Pharmacology·Bronwyn J Thomas, Janet C Wanstall
Jul 5, 2003·The Annals of Thoracic Surgery·Norikazu NomuraAkira Mishima
Dec 31, 2002·European Journal of Pharmacology·Doreen AwabdyJanet C Wanstall
Oct 7, 1998·European Journal of Pharmacology·K Homer, J Wanstall
Jul 20, 2002·Respiratory Physiology & Neurobiology·Larissa A ShimodaJ T Sylvester
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·T K CrilleyP A Bonnet
Jan 1, 1992·British Journal of Pharmacology·J C Wanstall, S R O'Donnell
Oct 1, 1991·The Journal of Pharmacy and Pharmacology·J C Wanstall, S R O'Donnell
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L JerniganThomas C Resta
Jun 21, 2012·Progress in Biophysics and Molecular Biology·Amy L FirthWon Sun Park
Mar 19, 2003·British Journal of Pharmacology·Debbie Y Y TsuiJanet C Wanstall
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·James E FaberHua Zhang
Feb 10, 1998·Journal of Cardiovascular Pharmacology·L BrownC Sernia
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K M ItoK Ito
Nov 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Minlin XuJason X-J Yuan

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