PMID: 25792766Mar 1, 2006Paper

Endothelin and endothelial dysfunction

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Tomoh Masaki, Tatsuya Sawamura

Abstract

Nitric oxide (NO) and endothelin (ET) produced in endothelial cells are leading molecules which regulate vascular function. Failure of the physiological balance between these two molecules is usually referred to as endothelial dysfunction. ET was initially identified as a potent vasoconstrictive peptide. Three ET isoforms and two ET receptors have been identified. One of the isoforms, ET-1, plays a significant role in many cardiovascular diseases. On the other hand, oxidized low-density lipoprotein (oxLDL) is known to induce endothelial dysfunction. The endothelial receptor for oxLDL was cloned, and named lectin-like oxidized receptor-1 (LOX-1). Activation of LOX-1 generates reactive oxygen species (ROS), and acivates a transcriptional factor, nuclear factor κB (NFκB), resulting in down-regulation of NO and up-regulation of ET-1. LOX-1 might be a key molecule in the generation of endothelial dysfunction. In endothelial dysfunction, ET-1 is an aggravating factor of cardiovascular diseases.

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Citations

Oct 1, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pitchai BalakumarManjeet Singh
Sep 23, 2014·Life Sciences·Noriaki EmotoMatthias Barton
Aug 28, 2012·Life Sciences·Matthias BartonTakashi Miyauchi
May 10, 2018·Angiology·Peter PoredosMateja Kaja Jezovnik
Jan 22, 2019·Current Medicinal Chemistry·Anastasios TentolourisNikolaos Tentolouris
Jul 9, 2020·Anatomia, histologia, embryologia·Juliane RiegerJohanna Plendl
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Kirsty A RobertsMark D Ross
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja

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