Endothelin blockade in angiotensin II hypertension: prevention and treatment studies in the rat

Clinical and Experimental Pharmacology & Physiology
S FicaiBernard Jover

Abstract

1. The participation of endothelin (ET) in the development and maintenance of hypertension induced by angiotensin (Ang) II was assessed using the non-specific ET receptor antagonist bosentan (30 mg/kg per day). 2. In the prevention study, bosentan was given 24 h prior to and during the 17 day period of AngII infusion (200 ng/kg per min, s.c., osmotic pump), whereas in the treatment study, bosentan was administered from day 10 to day 17. Tail-cuff pressure (TCP) was measured before and on days 10 and 17 of AngII infusion. At the end of studies, heart weight index was calculated as the ratio of heart to bodyweight (HWI) and the wall thickness of the carotid artery (perfusion/fixation at 120 mmHg) was measured. Tail-cuff pressure increased from 129 +/- 3 to 179 +/- 7 and 189 +/- 9 mmHg on days 10 and 17 of AngII infusion, respectively. 3. Final TCP was markedly lowered in rats pretreated with bosentan, whereas TCP remained comparable with untreated hypertensive rats when bosentan was given from day 10 of AngII infusion (177 +/- 9 mmHg). 4. The increase in cardiac mass associated with AngII hypertension was similarly attenuated in the two groups receiving bosentan. 5. The HWI was 3.49 +/- 0.12 mg/g in untreated hypertensive rats an...Continue Reading

References

Nov 1, 1996·Hypertension·S M BalakrishnanJ R McNeill

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Citations

Aug 3, 2004·Kidney & Blood Pressure Research·Pavel DvorákLudek Cervenka
Feb 3, 2005·Free Radical Biology & Medicine·Marc-André LaplanteJacques de Champlain
Oct 4, 2006·Hypertension·You-Lin Tain, Chris Baylis

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