Endothelin (ET)-1 induced mucosal damage in the rat small intestine: role of ET(A) receptors

Shock
S MassbergK Messmer

Abstract

The role of endothelin (ET)-1 as a mediator of small intestinal mucosal perfusion failure and tissue damage was investigated in the rat using intravital fluorescence videomicroscopy. The effects of intravenous infusion of ET-1 (3 nmol/kg) on functional capillary density, mucosal thickness, and the degree of mucosal damage were evaluated. Administration of ET-1 caused pronounced mucosal injury with a significant reduction of mucosal thickness compared with vehicle-treated control animals. Concomitantly, villous functional capillary density was markedly reduced 30 and 90 min after the infusion of ET-1. ET(A) receptor blockade by pretreatment with BQ 610 or with the novel ET(A) receptor antagonist ETR-P1/FL peptide prevented ET-1 induced capillary perfusion failure and mucosal damage. In contrast, the ET(B) receptor antagonist IRL 1038 was not effective. These results indicate that, acting via the ET(A) receptor, elevated levels of circulating ET-1 under various pathophysiological conditions, such as septic or hemorrhagic shock, might impair nutritive perfusion of the intestinal mucosa and contribute to tissue injury.

Citations

May 2, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ke-Xuan LiuZhengyuan Xia
Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Aug 26, 1998·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S MassbergK Messmer
Apr 25, 2013·Seminars in Pediatric Surgery·Daniel J Watkins, Gail E Besner
Sep 23, 2008·Regulatory Peptides·Roman M JanasMieczysław Szalecki
Mar 19, 2008·Seminars in Perinatology·Craig A NankervisKristina M Reber
Jul 22, 2008·The Journal of Surgical Research·Andreas AnderssonHans Hjelmqvist
Jun 24, 2005·The Journal of Pediatrics·Philip T NowickiDonna A Caniano
Jan 8, 2004·Acta Physiologica Hungarica·M Boros
Jan 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lauretta MassaiGiovanni Grasso
Feb 7, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·C E King-VanVlackP H MacDonald
Mar 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Berna K OktarHizir Kurtel

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