Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells

Biochemical and Biophysical Research Communications
A W Simpson, C C Ashley

Abstract

Endothelin (200 nM) evoked a rapid rise in [Ca2+]i which was then followed by a maintained elevation of [Ca2+]i. The initial transient can be explained by the release of stored Ca2+ whilst the maintained plateau is likely to be an influx of Ca2+ as it was partially inhibited by nifedipine (5 microM) and the remaining component abolished by the removal of extracellular Ca2+. Vasopressin (1 nM) evoked a similar response which also showed a nifedipine insensitive component to it's plateau phase. Endothelin also evoked oscillations in [Ca2+]i; these where characterised by a rapid rising phase followed by a slower decline, with no 'pacemaker' rise in [Ca2+]i preceding the rising phase. The oscillations were inhibited by the addition of 5 microM nifedipine or the removal of extracellular Ca2+ suggesting they are at least in part dependent on voltage gated Ca2+ entry.

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Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M KaiboriT Okumura
Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·N Miasiro, A C Paiva
Feb 26, 1991·European Journal of Pharmacology·P J KadowitzR K Minkes
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Jun 12, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·H Suenaga, K Kamata
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Christina VierlingWolfgang Vierling
Oct 13, 2005·Pharmacology & Therapeutics·Sophie MotteRobert Naeije
Jun 28, 1991·Biochemical and Biophysical Research Communications·J Chan, D A Greenberg
Aug 1, 1991·Circulation Research·C Chen, P K Wagoner
May 24, 2000·The Journal of Biological Chemistry·A Nassar, A W Simpson
Dec 1, 1991·The American Journal of Physiology·R MarsaultC Frelin

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