PMID: 9435598Jan 22, 1998Paper

Endothelin impairs ATP-sensitive K+ channel function after brain injury

The American Journal of Physiology
T Kasemsri, William M Armstead

Abstract

In piglets, pial arteries constrict, ATP-sensitive K+ (KATP) channel function is impaired, and cerebrospinal fluid endothelin-1 (ET-1) increases to 10(-10) M after brain injury [fluid percussion injury (FPI)]. Nitric oxide (NO) elicits dilation via guanosine 3',5'-cyclic monophosphate (cGMP) and KATP channel activation. This study was designed to characterize the relationship between ET-1 and impaired function of KATP channels after FPI. Injury was produced via the lateral FPI technique in piglets equipped with a closed cranial window. Cromakalim, a KATP agonist, produced dilation that was attenuated by FPI and partially restored by BQ-123, an ET-1 antagonist (11 +/- 1 and 23 +/- 2 vs. 2 +/- 1 and 4 +/- 1 vs. 8 +/- 1 and 17 +/- 2% for responses to 10(-8) and 10(-6) M cromakalim before FPI, after FPI, and after FPI with BQ-123, respectively). Because ET-1 constriction may antagonize dilation, separate experiments were conducted under conditions of equivalent baseline diameter in the absence and presence of ET-1 (10(-10) M). Cromakalim dilation was attenuated by ET-1 and partially restored by the protein kinase C (PKC) inhibitor staurosporine (12 +/- 1 and 28 +/- 1 vs. 2 +/- 1 and 21 +/- 3 vs. 9 +/- 1 and 29 +/- 2% for 10(-8) and...Continue Reading

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Citations

Jun 16, 1999·Journal of Neurotrauma·W M Armstead
Sep 29, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Shalinkumar PatelCharles W Leffler
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Ross, William M Armstead
Mar 5, 2003·Journal of Neurotrauma·William M Armstead
Jul 29, 2005·American Journal of Physiology. Renal Physiology·Chunhua CaoThomas L Pallone
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Dec 17, 2005·Journal of Applied Physiology·Jon AndresenRobert M Bryan

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