Endothelin in renal failure

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A N WarrensS R Bloom

Abstract

Endothelin is a 21-residue peptide vasoconstrictor produced by endothelium. Using a radioimmunoassay, endothelin values were measured in four groups of individuals: normal controls (0.54 +/- 0.12 pmol/l, n = 20); undialysed patients with chronic renal failure (CRF) (0.82 +/- 0.13 pmol/l, n = 38); chronic renal failure patients on continuous ambulatory peritoneal dialysis (CAPD) (2.81 +/- 0.63 pmol/l, n = 20); and patients with CRF on haemodialysis (HD) (4.52 +/- 1.21 pmol/l, n = 14). The endothelin values were significantly greater in undialysed patients with CRF when compared with controls (P less than 0.001) and significantly greater in both dialysis groups when compared with controls and the undialysed CRF group (P much less than 0.001). The difference between the two dialysis groups was not significant (P = 0.07). There was no correlation between endothelin and serum creatinine, mean arterial pressure, presence of chronic hypertension and/or diabetes, use of calcium-channel blockers and/or ACE inhibitors, or primary renal diagnostic category. A single haemodialysis session had no significant effect on endothelin values in the ten patients in whom this was assessed. Fast protein liquid chromatography (FPLC) appeared to confi...Continue Reading

Citations

Nov 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S OzdemirZ Koray
Feb 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I BlazyC Sachs
Sep 12, 2000·Current Hypertension Reports·R R WenzelT Philipp
May 30, 1997·European Journal of Pharmacology·B PalaciosC C Pang
May 20, 1999·Transplantation Proceedings·D GrekasA Tourkantonis
Jul 13, 2001·Pharmacology & Therapeutics·S Naicker, K D Bhoola
Jun 24, 1999·Immunology Today·A R SimonM Sykes
Apr 12, 2002·Resuscitation·Andreas WagnerAnton N Laggner
Aug 1, 1997·Journal of the American College of Cardiology·D S Celermajer
Feb 19, 2002·Kidney International·Dominic S C RajRichard A Robbins
Nov 13, 2002·Kidney International·Laetitia DouYvon Berland
Aug 10, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·D X DengS Chakrabarti
Jun 4, 2008·Nephrology·Alessandro PalermoSantina Cottone
Oct 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan
Jun 1, 1997·Kidney International·G M London, T B Drueke
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dan WenRu-Tai Hui
Nov 21, 2009·Journal of Clinical Laboratory Analysis·Ivanka MikulićMonika Zeljko-Tomić
Jun 4, 2014·Journal of Cardiac Surgery·Antonio SegretoFederico Bizzarri
Mar 2, 2016·Anesthesiology Clinics·Selma Ishag, Charuhas V Thakar
Oct 13, 1998·Renal Failure·L BankirR C Blantz
Dec 24, 1997·Hypertension·S G GreenbergK E Clark
Apr 29, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J BlacherG M London
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M F HandD J Webb
Sep 13, 2005·Renal Failure·Vasilios LiakopoulosIoannis Stefanidis
Jun 24, 2008·Clinical and Experimental Nephrology·E M El-ShafeyA A Sabry
Apr 1, 1996·Clinical and Experimental Pharmacology & Physiology·P Nambi
Apr 30, 1992·Biochemical and Biophysical Research Communications·M TakaiT Okada
Jan 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B Watschinger, M H Sayegh
Jan 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.