Endothelin-induced facilitation of sympathetic neurotransmission to the rat vas deferens: effects of suramin

European Journal of Pharmacology
W A LauJ N Pennefather

Abstract

Experiments were conducted to elucidate the mechanisms of action of endothelins in facilitating neurotransmission to the rat isolated vas deferens. Endothelin-1 and endothelin-3 potentiated field stimulation-induced contractions and those evoked by ATP and alpha, beta-methylene ATP. Responses to noradrenaline were unaffected. The C-terminal hexapeptide, endothelin-(16-21) was without effect on neurotransmission. The facilitation by endothelin-1 of responses to trains of stimulation (10 Hz for 10 s) was absent in the presence of the P2-purinoceptor antagonist, suramin, in concentrations which antagonised the contractile effects of alpha, beta-methylene ATP, but not those of noradrenaline. Suramin did not affect 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)- phenyl]-3-pyridine carboxylic acid methyl ester (Bay K 8644)-induced potentiation of contractions in response to field stimulation. These results support the hypothesis that endothelin-induced facilitation of sympathetic neurotransmission to the vas deferens is due to potentiation of the postjunctional effects of the co-transmitter, ATP, acting at P2X-purinoceptors, and indicate that this effect is mediated through actions at endothelin receptors that are not of the...Continue Reading

References

Sep 10, 1992·European Journal of Pharmacology·N MallardB Spriggs
Mar 25, 1991·Biochemical and Biophysical Research Communications·D L WilliamsB V Clineschmidt
Aug 21, 1990·European Journal of Pharmacology·N P WiklundL E Gustafsson
Sep 28, 1990·Biochemical and Biophysical Research Communications·K OkadaM Yano
Mar 17, 1987·European Journal of Pharmacology·N I Amobi, I C Smith
Feb 1, 1988·British Journal of Pharmacology·P M Dunn, A G Blakeley
Apr 1, 1971·Acta Physiologica Scandinavica·G Swedin

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Citations

Feb 5, 1999·European Journal of Pharmacology·A FilippelliF Rossi
Aug 24, 1999·British Journal of Pharmacology·W A LauF J Mitchelson
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuko TsuchiyamaIchiro Nishio
Sep 29, 2011·Neurourology and Urodynamics·José Luis ArteagaMedardo Hernández
Feb 10, 2017·American Journal of Physiology. Renal Physiology·Eman Y GoharDavid M Pollock
Aug 19, 2007·Neurourology and Urodynamics·K-E Andersson
Sep 4, 2004·Journal of Receptor and Signal Transduction Research·Makoto YonoRobert M Weiss

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