Endothelin-mediated vascular tone following focal cerebral ischaemia in the cat

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
T R PatelJ McCulloch

Abstract

The actions of Bosentan and PD155080, nonpeptide endothelin receptor antagonists, were examined in feline pial arterioles in situ following middle cerebral artery (MCA) occlusion to gain insight into the cerebrovascular influence of endogenous endothelins in focal cerebral ischaemia. Immediately following permanent MCA occlusion, all pial arterioles overlying the suprsylvian and ectosylvian gyri displayed marked dilatations, which were maintained in a population of vessel but differentiated into sustained constrictions in others. Perivascular subarachnoid microinjections of Bosentan (30 microM), PD155080 (30 microM), and artificial CSF (pH 7.2) were performed between 30 and 210 min following MCA occlusion. The perivascular microapplication of Bosentan (30 microM) and PD155080 (30 microM) around pial vessels overlying the suprasylvian and ectosylvian gyri, which are within the territory of the occluded MCA, elicited in increase in the calibre of postocclusion dilated and constricted pial arterioles. The perivascular microapplication of PD155080 (30 microM) around postocclusion constricted arterioles overlying the ectosylvian and suprasylvian gyri elicited an increase in the calibre of arterioles (69 +/- 49% from preinjection bas...Continue Reading

References

Nov 1, 1992·Journal of Molecular and Cellular Cardiology·F BrunnerL H Opie
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·I ZivM Sokolovsky
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Jul 1, 1990·The Journal of Clinical Investigation·M E LeeT Quertermous
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J Robinson, J McCulloch
Mar 31, 1989·Biochemical and Biophysical Research Communications·H KuriharaY Yazaki
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A GiaidJ M Polak
Dec 1, 1989·Acta Physiologica Scandinavica·T HökfeltL Terenius
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E OzyurtJ McCulloch
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S Hatashita, J T Hoff
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L BrandtG Teasdale
Jul 21, 1994·European Journal of Pharmacology·T R PatelJ McCulloch
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·D Venarucci
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·E H OhlsteinJ S Frazee
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G I FegerM Wahl
Mar 1, 1993·The American Journal of Physiology·R MarsaultC Frelin
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F C BaroneE H Ohlstein
Aug 2, 1993·European Journal of Pharmacology·R NikolovJ Krieglstein
Jul 1, 1993·British Journal of Pharmacology·J B SalomE Alborch
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J SharkeyP A Kelly
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I M MacraeJ McCulloch
Jan 1, 1992·The European Journal of Neuroscience·Martine TencéJoël Prémont

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Citations

Sep 30, 2000·European Journal of Pharmacology·L R WhiteJ Aasly
Apr 4, 2007·Journal of Neurotrauma·Ji-Yao LiTakehiko Yanagihara
Jul 23, 2008·Journal of Cardiovascular Pharmacology·Jeffrey J IliffG Alexander West
Mar 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suyi CaoRaymond C Koehler
Jul 5, 2005·Expert Opinion on Investigational Drugs·V BreuM Clozel
Oct 30, 2007·European Journal of Pharmacology·David NilssonMalin Malmsjö
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C GörlachM Wahl
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O TouzaniJ McCulloch
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A BhardwajR J Traystman
Nov 9, 2006·Experimental Brain Research·Marie HenrikssonLars Edvinsson
Nov 25, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·B Battistini, P Dussault
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Annette RebelRaymond C Koehler

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