Endothelin production in cultured vascular smooth muscle cells--modulation by the atrial, brain, and C-type natriuretic peptide system

Metabolism: Clinical and Experimental
T HanehiraJ Yoshikawa

Abstract

We examined the regulatory mechanisms of endothelin-1 (ET-1) production in cultured rat vascular smooth muscle cells (VSMC) with a special focus on the roles of protein kinase C (PKC)- and cyclic guanosine-3',5'-monophosphate (GMP)-mediated signaling systems. Effects of atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP) on angiotensin II (Ang II)-, and arginine vasopressin (AVP)-induced production of ET-1 were examined in cultured rat aortic VSMC. Ang II and AVP stimulated ET-1 production in a concentration-dependent manner through angiotensin subtype 1 (AT1) and vasopressin subtype 1 (V1) receptors, respectively. The stimulatory effects of Ang II and AVP were markedly abolished in PKC-depleted cells. Rat ANP (1-28), rat BNP-45, and rat CNP-22 potently inhibited Ang II- and AVP-stimulated ET-1 production in a concentration-dependent manner, respectively. The inhibitory effect by CNP on ET-1 production was paralleled by an increase in the cellular level of cyclic GMR.8-Bromo cyclic GMP reduced the stimulated ET-1 production by Ang II and AVP. These results indicate that Ang II and AVP stimulate ET-1 production in cultured rat VSMC through AT1 and V1 receptors by a mechanism probably involving activation of PKC, a...Continue Reading

References

Dec 1, 1990·Journal of Cardiovascular Pharmacology·R S ZimmermanR W Barbee
Jan 1, 1991·Journal of Cardiovascular Pharmacology·S M KanseS R Bloom
Feb 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M KohnoT Takeda
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss

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Citations

Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Jan 26, 2008·Journal of Applied Physiology·Bradley J BehnkeMichael D Delp
May 23, 2002·Journal of Hypertension·Hans Peter Brunner-La RoccaMurray D Esler
Apr 13, 2004·Lippincott's Case Management : Managing the Process of Patient Care·Sandra L LoweryClyde W Yancy
Jun 25, 2004·Lippincott's Case Management : Managing the Process of Patient Care·Sandra L LoweryClyde W Yancy
Apr 27, 2021·Frontiers in Physiology·Agnaldo Bruno ChiesLuis Gabriel Navar

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