Endothelin production links superoxide generation to altered opioid-induced pial artery vasodilation after brain injury in pigs

Stroke; a Journal of Cerebral Circulation
T Kasemsri, W M Armstead

Abstract

Traumatic brain injury conveys significant morbidity and mortality to infants and children. In the newborn pig, opioids contribute to pial artery vasconstriction after fluid percussion injury (FPI). FPI attenuates vasodilation and cGMP production by methionine enkephalin (Met) and leucine enkephalin (Leu) and reverse dynorphin (Dyn) from a dilator to a constrictor. Superoxide anion (O2-) production contributes to altered cerebral hemodynamics after FPI, and O2- scavengers partially restore decreased dilator responses after FPI. Endothelin-1 (ET-1), a purported mediator of cerebral vasospasm, has been suggested to alter nitric oxide function and cGMP concentration. The present study was designed to determine the contribution of ET-1 to altered opioid-induced dilation after FPI and the role of O2- in such altered responses. Injury of moderate severity (1.9 to 2.3 atm) was produced by the lateral FPI technique in anesthetized newborn pigs equipped with a closed cranial window. Superoxide dismutase (SOD)-inhibitable nitroblue tetrazolium (NBT) reduction was determined as an index of O2- generation. FPI increased cerebrospinal fluid ET-1 from 20 +/- 2 to 93 +/- 6 pg/mL (approximately 10(-10) mol/L). Topical ET-1 (10(-10) mol/L) incr...Continue Reading

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Citations

Mar 26, 2013·Translational Stroke Research·Jennifer KostyWilliam M Armstead
Nov 7, 2000·Journal of Cardiovascular Pharmacology·M FerrerG Balfagón
Apr 7, 1999·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·W M Armstead
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·William M Armstead
Dec 17, 2005·Journal of Applied Physiology·Jon AndresenRobert M Bryan
Mar 17, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·John Q Liu, Rodney J Folz
Dec 18, 2002·Experimental Biology and Medicine·William M Armstead
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chi Dae KimKi Whan Hong
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Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Ross, William M Armstead
Jan 22, 1998·The American Journal of Physiology·T Kasemsri, W M Armstead

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