Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish.

PLoS Genetics
Karen Camargo-SosaRobert N Kelsh

Abstract

Skin pigment patterns are important, being under strong selection for multiple roles including camouflage and UV protection. Pigment cells underlying these patterns form from adult pigment stem cells (APSCs). In zebrafish, APSCs derive from embryonic neural crest cells, but sit dormant until activated to produce pigment cells during metamorphosis. The APSCs are set-aside in an ErbB signaling dependent manner, but the mechanism maintaining quiescence until metamorphosis remains unknown. Mutants for a pigment pattern gene, parade, exhibit ectopic pigment cells localised to the ventral trunk, but also supernumerary cells restricted to the Ventral Stripe. Contrary to expectations, these melanocytes and iridophores are discrete cells, but closely apposed. We show that parade encodes Endothelin receptor Aa, expressed in the blood vessels, most prominently in the medial blood vessels, consistent with the ventral trunk phenotype. We provide evidence that neuronal fates are not affected in parade mutants, arguing against transdifferentiation of sympathetic neurons to pigment cells. We show that inhibition of BMP signaling prevents specification of sympathetic neurons, indicating conservation of this molecular mechanism with chick and mo...Continue Reading

References

Sep 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D W RaibleJ S Eisen
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Mar 24, 1995·Science·A Levitzki, A Gazit
Jul 11, 1998·The Journal of Biological Chemistry·M F FavataJ M Trzaskos
Sep 14, 2000·Developmental Biology·R N KelshJ S Eisen
Jul 15, 2004·Pigment Cell Research·Robert N Kelsh
May 18, 2006·Pigment Cell Research·Eve M Mellgren, Stephen L Johnson
Jan 11, 2007·BMC Genomics·Robert GeislerChristiane Nüsslein-Volhard
Nov 21, 2007·Nature Chemical Biology·Paul B YuRandall T Peterson
Mar 29, 2008·PLoS Genetics·Susana S LopesRobert N Kelsh
Apr 18, 2008·Developmental Biology·James E N Minchin, Simon M Hughes
Oct 28, 2008·Bioorganic & Medicinal Chemistry Letters·Stephen D BarrettHaile Tecle
Nov 4, 2008·Seminars in Cell & Developmental Biology·Robert N KelshCarol A Erickson
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Takahiro SatoHiroki Kurihara
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Prisca ChapoutonLaure Bally-Cuif
Aug 5, 2010·American Journal of Medical Genetics. Part a·David E ClouthierThomas F Schilling
Jan 19, 2012·Pigment Cell & Melanoma Research·Sarah ColanesiE Elizabeth Patton
Apr 24, 2012·Genesis : the Journal of Genetics and Development·Frederico S L M RodriguesRobert N Kelsh
Nov 26, 2013·American Journal of Human Genetics·Christopher T GordonJeanne Amiel
Apr 30, 2014·Nature Cell Biology·Ajeet Pratap SinghChristiane Nüsslein-Volhard
Aug 30, 2014·Science·Sarah K McMenaminDavid M Parichy
Oct 7, 2014·Nature Cell Biology·Cristina OttoneSimona Parrinello
Nov 26, 2014·Pigment Cell & Melanoma Research·David M Parichy, Jessica E Spiewak
Jan 21, 2015·Current Biology : CB·Ajeet Pratap Singh, Christiane Nüsslein-Volhard
Aug 4, 2015·Mechanisms of Development·Daisuke Saito, Yoshiko Takahashi
Aug 8, 2015·Pigment Cell & Melanoma Research·Manfred SchartlRobert N Kelsh
Mar 13, 2016·Current Topics in Developmental Biology·Uwe IrionChristiane Nüsslein-Volhard
Jul 28, 2016·Developmental Cell·Ajeet Pratap SinghChristiane Nüsslein-Volhard
Nov 5, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroki KawaiShohei Furutachi

❮ Previous
Next ❯

Citations

May 30, 2019·ELife·Lauren M SaundersDavid M Parichy
Sep 12, 2019·Annual Review of Genetics·Larissa B Patterson, David M Parichy
May 25, 2021·The Journal of Heredity·Chenxu WangDeshou Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
GTPase
transgenic
PCR
electrophoresis
chemical treatment
dissection
fluorescence imaging

Software Mentioned

Gen
Fiji
Adobe Photoshop
Primer3
Genetools
Tools

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.