Endothelin-receptor antagonists for diabetic nephropathy: A meta-analysis

Nephrology
Wenming YuanPing Fu

Abstract

Endothelin-receptor antagonists may be a novel therapeutic strategy for diabetic nephropathy, but their use remains controversial. This meta-analysis seeks to evaluate the effectiveness and safety of endothelin-receptor antagonists for patients with diabetic nephropathy. Literature reviews of the PubMed, EMBASE and CENTRAL databases were conducted to identify randomized controlled trials (RCTs) comparing endothelin-receptor antagonist treatment with placebo in patients with diabetic nephropathy. Quality assessment was performed by using the Cochrane Handbook's tools for assessing risk of bias; meta-analysis was conducted by RevMan 5.3. Five RCTs (n=2034 patients) were included for analysis. Compared with placebo, endothelin-receptor antagonists showed significant benefits for lowering albuminuria (five trials, n=2034 patients; SMD 0.66 95% confidence interval (CI) 0.56 to 0.76), but there was no significant difference in the risk of death (two trials, n=1674 patients; RR 1.49 95% CI 0.81 to 2.76). In addition, risk of cardiovascular events and other serious adverse events were significantly higher in the endothelin-receptor antagonists group than the placebo group (four trials, n=1956 patients; RR 1.45 95% CI 1.07 to 1.97; five...Continue Reading

References

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Citations

Jun 13, 2015·Current Hypertension Reports·Sheldon TobeRanjit Singarayer
Jun 9, 2016·Journal of Medicinal Chemistry·John-David Aubert, Lucienne Juillerat-Jeanneret
May 19, 2017·Current Opinion in Nephrology and Hypertension·Panagiotis I Georgianos, Rajiv Agarwal
Nov 5, 2019·Hypertension·Matthias Barton, Masashi Yanagisawa
Apr 2, 2020·Frontiers in Physiology·Lauren G DoumaMichelle L Gumz

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