Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates

Surgery
T FoitzikH J Buhr

Abstract

We previously demonstrated that therapy with a new endothelin A receptor antagonist (ET-RA) significantly reduced mortality rates in severe acute pancreatitis (AP) in the rat without attenuating local signs of disease severity (intrapancreatic protease activation, acinar cell necrosis). This raised the question as to why ET-RA was so effective. The purpose of this study was to assess the effect of ET-RA on microcirculation (particularly capillary permeability) within and outside of the pancreas on intravascular fluid loss and extravascular fluid sequestration and on distant organ function. Severe AP was induced in rats by standardized intraductal bile acid infusion and cerulein hyper-stimulation. Starting 6 hours (n = 24 rats) and 12 hours (n = 30 rats) after the onset of AP, animals randomly received either the ET-RA (LU-135252) or saline solution with fluid resuscitation (6 mL/kg/h Ringer's lactate). At 24 hours, animals were relaparotomized for intravital microscopic determination of capillary blood flow, leukocyte rolling, and capillary permeability in the pancreas and colon. Further monitoring included cardiorespiratory and renal parameters, hematocrit levels and quantification of ascites and pleural effusions, and acinar ...Continue Reading

References

Jul 27, 2006·Journal of Gastroenterology·Hidehiro SawaYoshikazu Kuroda
Jan 5, 2005·Digestive Diseases and Sciences·S Ian Gan, Joseph Romagnuolo
Jul 27, 2006·Digestive Diseases and Sciences·Martin KruschewskiHeinz J Buhr
Apr 15, 2006·Digestive Diseases and Sciences·Martin KruschewskiChristoph Loddenkemper
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T Foitzik
Apr 21, 2007·Journal of Zhejiang University. Science. B·Xi-ping ZhangJie Zhang
Feb 8, 2008·Journal of Zhejiang University. Science. B·Xi-ping ZhangHan-qin Chen
Jul 1, 2009·Journal of Gastroenterology·Takeo YasudaYoshifumi Takeyama
Mar 23, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anna Andrzejewska, Jan W Dlugosz
Jul 1, 2008·Microvascular Research·Dirk UhlmannHelmut Witzigmann
Apr 12, 2006·The British Journal of Surgery·C M Cuthbertson, C Christophi
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jan W DlugoszEugeniusz Wroblewski
Oct 8, 2011·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yong-Feng ChenZhong-Min Wu
Nov 6, 2012·Journal of Zhejiang University. Science. B·Jing-min OuPing Yan
May 22, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pankaj Singh, Pramod Kumar Garg
Nov 28, 2002·The Annals of Pharmacotherapy·Alexander A Fisher, Mark L Bassett
Aug 7, 2013·Experimental Biology and Medicine·Zhiyao ChenHeguang Huang
Jan 5, 2002·The European Journal of Surgery = Acta Chirurgica·E AlhanR Cicek
Nov 7, 2019·Physiological Reports·Fahad MunirZhang Qiyu
Mar 3, 2004·Scandinavian Journal of Gastroenterology·R SegersvärdJ Permert
Aug 10, 2004·World Journal of Gastroenterology : WJG·Marek DoboszZdzislaw Wajda
Jan 27, 2006·World Journal of Gastroenterology : WJG·José M Remes-TrocheGuillermo Robles-Díaz
May 20, 2015·Expert Review of Gastroenterology & Hepatology·Vikesh K SinghEnrique de-Madaria
Jun 5, 2002·World Journal of Gastroenterology : WJG·Zong-Guang Zhou, You-Dai Chen
Dec 11, 2014·World Journal of Gastroenterology : WJG·Jing LiCheng-Wei Tang

Citations

Jan 1, 1992·Life Sciences·K TakaoriT Tobe
Jan 1, 1992·Annals of Surgery·J SchmidtA L Warshaw
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P G LankischG Rahlf
Mar 1, 1995·Scandinavian Journal of Gastroenterology·X H LiuH Nawata
Feb 1, 1996·Virchows Archiv : an International Journal of Pathology·C J KirkpatrickB Klosterhalfen
May 1, 1996·World Journal of Surgery·A Gullo, G Berlot
Sep 1, 1997·Gastroenterology·S TennerP A Banks
Jan 1, 1997·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·T FoitzikH J Buhr
Jul 29, 1999·The Journal of Surgical Research·T PlusczykG Feifel
Jul 6, 2000·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Bence ForgacsT Foitzik
Aug 23, 2000·International Journal of Colorectal Disease·T FoitzikH J Buhr

Related Concepts

Fluid Loss
Necrosis
Bile Acid Measurement
Dioxygen
Salicylhydroxamic acid
Acute Pancreatitis
Capillary Permeability
Autopsy
Pancreatitis
Diastolic Blood Pressure

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.