Endothelin receptor expression in human decidua

Molecular Human Reproduction
G KohnenI T Cameron

Abstract

The endothelins are signalling peptides that act via two receptors, ET(A) and ET(B). In the human endometrium, endothelin receptors have been demonstrated in glands and stroma and have been shown to vary during the course of the menstrual cycle. The present study was undertaken to determine whether or not expression of endothelin receptors changes during pregnancy or after administration of exogenous progestagens. The expression of the receptors was correlated with the appearance of basement membrane components during decidualization of the endometrial stroma. Decidual specimens (n = 15) were obtained during the first trimester of pregnancy and 10 at term. Sixteen pairs of endometrial biopsies were obtained from women with menorrhagia before and after exposure to exogenous progestagens. A total of 15 hysterectomy specimens were used as controls for the expression of stromal basement membrane proteins in the absence of decidualization. Autoradiography was carried out with selective ligands for ET(A) ([125I]-PD 151242) and ET(B) ([125I]-BQ3020). The distribution of ligand binding was then compared with the distribution of laminin alpha2 light chain and collagen IV. ET(A), ET(B), laminin alpha2 light chain, and collagen IV were ex...Continue Reading

Citations

Jun 8, 2007·Biology of Reproduction·Larry G ThaeteMark G Neerhof
Mar 5, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·I T Cameron
Apr 11, 2018·Current Hypertension Reports·Joey P GrangerBhavisha A Bakrania
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley

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